摘要
目的探讨灵芝孢子油体内抗Friend鼠白血病病毒(Friend murine leukemia virus,Fr.MuLV)感染的疗效和作用机制。方法用Fr.MuLV感染BALB/C雌性小鼠,造模小鼠ig给药21d,比较各组动物的体质量、脾指数、胸腺指数,CD4+、CD8+、CD4+/CD8+等指标变化情况。结果小鼠感染Fr.MuLV后体质量严重减轻,脾明显肿大,胸腺萎缩,CD4+、CD8+、CD4+/CD8+值均显著降低。灵芝孢子油50、100、200mg/kg剂量均可显著改善体质量增长抑制、脾肿大及胸腺萎缩(P<0.01),100、200mg/kg剂量组CD4+、CD8+、CD4+/CD8+值均有明显升高(P<0.01、0.05)。结论灵芝孢子油对Fr.MuLV感染小鼠有保护作用,能够改善体质量增长抑制,抑制脾肿大及胸腺萎缩,升高感染小鼠的T淋巴细胞。
Objective To study the effects of ganoderma spore oil on Friend murine leukemia virus （Fr. MuLV） and its mechanism. Methods The BALB/C female mouse was infected with Fr. MuLV, body weight, spleen index, thymus index, the percentages of CD4^＋ , CD8^- , and CD4^＋/CD8^＋ were measured. Results Compared to the eontrol group, body weight extenuation, splenomegaly, and atrophy of thymus gland severely in the model group, the percentages of CD4^ ＋ , CD8 ^＋ , and CD4^＋/CD8 ^＋ were significantly decreased in the model. Body weight, spleen index, and thymus index （P〈0.01） in ganoderma spore oil group were improved with the dosage of 50, 100, and 200 mg/kg, the percentages of CD4^＋ CD8^＋ and CD4^＋/CD8^＋ were cut down （P〈0.01 and 0.05） with the dosage of 100 and 200 mg/kg. Conclusion Ganoderma spore oil can protect the Fr. MuLV-infected model mouse by improving body weight extenuation, inhibiting splenomegaly and atrophy of thymus gland, and increasing T lymphocyte.
出处
《中草药》
CAS
CSCD
北大核心
2010年第3期423-426,共4页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目("岭南地产药材抗流感病毒药效物质基础"
编号u0732004)
