摘要
目的:探讨妊娠和子代结局与助孕方式的相关性。方法:回顾性统计分析2002.03～2008.07期间本中心所有ARTs助孕并妊娠的周期。按IUI、IVF-ET等助孕方式分组,比较妊娠、子代情况。结果:临床妊娠683个周期,新生儿701例,出生缺陷15例,出生缺陷率各种助孕方式间无统计学差异。早期流产率ICSI方式高于常规IVF方式;常规IVF的宫外孕率高于ICSI;出生多胎率IVF-ET组高于IUI组,P均<0.05。IVF-ET与IUI比、常规IVF与ICSI比,多胎比单胎均有更高的剖宫产率,P<0.05或P<0.01。出生婴儿男女比例为1∶1.03,单胎比多胎有更高的男孩比例,P<0.05。IVF-ET与IUI比,多胎比单胎早产率高,P<0.05或P<0.01。结论:ICSI和FET操作未明显增加新生儿出生缺陷风险,但其子代遗传风险可能偏高;常规IVF比ICSI有更高的宫外孕和剖宫产风险;IVF-ET产科风险高于IUI。
Objective：To explore the relevance between different treatment methods and the outcome of pregnancy and offspring.Methods： A retrospective study was conducted on all pregnancy cycles after ARTs from March 2002 to July 2008.Results： There were 15 newborns with birth defects among 701 babies born after 683 clinical pregnancy cycles.And there was no significant difference of birth defects rate between IVF-ET group and IUI group.The early abortion rate of ICSI subgroup was higher than that of common IVF subgroup,and the multiple birth rate of IVF-ET was higher than that of IUI,P〈0.05.The cesarean section rate of IVF-ET was higher than that of IUI,as common IVF vs ICSI,multiples vs singletons,P〈0.01,0.05 and 0.01,separately.Male to female ratio among newborns was 1∶1.03,and the proportion of boys among singletons was higher than that among multiples,P〈0.05.The premature birth rate of IVF-ET was higher than that of IUI,as multiples vs singletons,P〈0.05 and 0.01,separately.Conclusions： There is no significant increase in birth defect rate after ICSI and FET,but it cannot be ruled out that the genetic risk of ICSI is higher than that of common IVF.And the obstetric risk of IVF-ET is higher than that of IUI.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2010年第2期98-104,共7页
Reproduction and Contraception
