摘要
目的拟用SPECT脑血流灌注显像研究甲状腺功能亢进症（简称甲亢）患者脑血流改变模式，并分析可能相关因素。方法年龄、性别、文化程度相匹配的25例甲亢患者和22名健康对照者于静脉注射^99Tc^m-双半胱乙酯（ECD）1110MBq后30min行静息SPECT脑灌注显像。应用统计参数图5．0软件（SPM5）对甲亢和对照者脑灌注图像进行体素对体素的团体t检验（P〈0．05，校正）。应用基于TMairach图谱的脑功能自动提取法获取各个脑功能区的血流半定量值。血清FT3、FT4、高灵敏促甲状腺激素（sTSH）、甲状腺过氧化物酶抗体（TPOAb）、促甲状腺激素受体抗体（TRAb）浓度与脑灌注相关性应用单因素Pearson相关分析，病程与脑灌注相关性应用单因素Spearman相关分析。结果甲亢患者大脑边缘系统、额叶血流灌注减低。边缘系统血流减低的部位主要包括海马钩回、两侧海马旁回（后内嗅皮质、后旁嗅皮质、海马旁皮质、前扣带回、右侧颞下回）和左侧下丘脑及尾状核体（P〈0．05，校正）。额叶血流减低部位包括左侧前体感联合皮质、前运动皮质、额叶眼动区（t=5．87，P〈0．05，校正）。甲亢患者左侧舌回、后扣带回血流灌注与FL浓度呈负相关（r=-0．468，-0．417，P均〈0．05）。左侧舌回、两侧颞下回、右侧顶上小叶血流与FT4浓度呈负相关（r=-0．434，-0．418，-0．415，-0．459，P均〈0．05），左侧乳头体、左侧壳核血流与FT4浓度呈正相关（r=0．419，0．412，P均〈0．05）。左侧岛叶血流与sTSH呈负相关，右侧听觉联合皮质血流与sTSH呈正相关（r=-0．504，0．429，P均〈0．05）。左侧颞中回、左侧角回血流与TRAb呈正相关（r=0．750，0．862，P均〈0．05），右侧丘脑、右侧下丘脑、左侧前核、左侧腹侧核血流与TRAb呈负相关（r=-0．691，-0．835，-0．713，-0．759，P均〈0．05）；右侧前扣带�
Objective To investigate the cerebral blood flow （CBF） perfusion patterns and related factors in hyperthyroidism patients. Methods Twenty-five patients with hyperthyroidism and twenty-two healthy controls matched for age, sex, education were enrolled. ^99 Tc^m -ethylene cysteinate dimer （ECD） SPECT CBF perfusion imaging was performed at rest. Statistical parametric mapping 5.0 software （ SPM5 ） was used and a statistical threshold of P 〈 0.05 （corrected） was applied for signifying changes of regional CBF （rCBF）. The semiquantitative values of rCBF were extracted automatically by brain search 1.1 software and were correlated with concentrations of serum thyroid hormones （ FT3, FT4 ）, thyroid autoimmune antibodies： sensitive thyroid stimulating hormone （sTSH）, thyroid peroxidase antibody （TPOAb） and TSH receptor antibody （TRAb） by Pearson analysis, with disease duration by Spearman analysis. Results rCBF was decreased significantly in limbic system and frontal lobe, including parahippocampal gyrus, uncus （posterior entorhinal cortex, posterior parolfactory cortex, parahippocampal cortex, anterior cingulate, right inferior temporal gyrus）, left hypothalamus and caudate nucleus （P 〈0. 05, corrected）, rCBF in left lingual gyrus, posterior cingnlated was negatively correlated with concentration of FT3 （ r = - 0. 468, - 0.417, both P 〈 0.05 ）. rCBF in left lingual gyrus, bilateral inferior temporal gyrus, right superior parietal lobe was negatively correlated with concentration of FT4 （ r = - 0.434, - 0.418, - 0. 415, - 0. 459, all P 〈 0.05 ）, while thatin left mammillary body and putamen was positively correlated with concentration of FT4 （r = 0. 419, 0. 412, both P 〈 0. 05 ）. rCBF in left insula was negatively correlated with concentration of sTSH, and right auditory associated cortex was positively correlated with concentration of sTSH （ r = - 0. 504, 0. 429, both P 〈 0.05 ）. rCBF in left middle temporal gyrus, left angular gyrus was positively
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2010年第1期46-50,共5页
Chinese Journal of Nuclear Medicine
