摘要
目的探讨医院肿瘤患者肺部感染病原菌的耐药现状,为临床合理使用抗菌药物提供科学依据。方法统计分析肿瘤患者的临床资料;细菌鉴定采用法国生物梅里埃公司VITEK32全自动细菌分析系统;药敏试验用K-B法进行。结果导致肺部感染的287株病原菌中居前5位的是:铜绿假单胞菌(17.8%)、鲍氏不动杆菌(16.7%)、金黄色葡萄球菌(13.6%)、肺炎克雷伯菌(12.2%)、大肠埃希菌(8.7%);产ESBLs肠杆菌科细菌检出率为43.3%;耐甲氧西林金黄色葡萄球菌(MRSA)检出率为41.0%。结论肿瘤患者肺部感染病原菌的耐药性已十分严重,应采取综合性干预措施,控制医院感染暴发流行。
OBJECTIVE To investigate the drug resistance status of pathogens in pulmonary infection in cancer patients and provide the scientific evidence for clinically reasonable use of antibiotics. METHODS The clinical data of cancer patients were analyzed statistically. VITEK 32 produced by bioMérieux was used to identify the strains. Drug sensitivity testing was performed by K-B methods. RESULTS Among 287 strains of pathogens causing pulmonary infection,the top five were Pseudomonas aeruginosa （17.8%）,Acinetobacter baumannii （16.7%）,Staphylococcus aureus （13.6%）,Klebsiella pneumoniae （12.2%）,and Escherichia coli （8.7%）. The detection rate of extended-spectrum beta-lactamases （ESBLs） producing Enterobacteriaceae was 43.3%. That of meticillin-resistant S. aureus （MRSA） was 41.0%. CONCLUSIONS Drug resistance status of pathogens in pulmonary infection in cancer patients is very serious. We should take comprehensive intervention measures to control its outbreak.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第5期727-729,共3页
Chinese Journal of Nosocomiology
关键词
肿瘤患者
肺炎
医院感染
病原菌
耐药性
Cancer patients
Pneumonia
Nosocomial infections
Pathogens
Drug resistance
