摘要
目的：观察８４例口腔粘膜鳞状细胞癌术前诱导化疗后肿瘤缩小的程度。方法：实验室检查（血小板、血色素、白细胞计数和肝、肾功能），消化道反应和术中、术后的相关症状。结果：肿瘤缩小以化疗后第７～１４天最为显著；全血下降从第３天开始，到第１４天停止，第２０天恢复到正常下限水平；肾毒性起自第３天，第１４天左右结束；消化道反应中的食欲下降可一直维持到第１４天以后。通过本组的研究资料表明：诱导化疗后手术时机的选择和疗效、预后及术后机体的恢复有着密切的关系。结合对照组中１２例行姑息化疗患者肿瘤再生长的时间。结论：术前高剂量诱导化疗后手术时机的选择以化疗起始第２１天左右为宜。
Objective: This article reported the shrinking degree of the oral mucosa squamous carcinoma size after induced chemotherapy. Methods: the laboratory examination outcomes(BPC,Hb,WBC, the functions of liver and kidney), reaction of the digestive tract and related symptoms during operation and post operation in 84 cases. Results: the size of the carcinoma shrinked significantly from the 7th to the 14th day after the induced chemotherapy, and all the indexes of hematological examination decreased between the 3rd and the 14th day and began to return to normal values on the 20th day. The results also showed that the nephrotoxins occurred from the 3rd to the 14th day but disppeared on the 20th day and the anorexia lasted for 14 days after the induced chemotherapy. Conclusion: there is close relationship between the chosing of the optimal operating time after the induced chemotherapy and the therapeutic effect, prognosis, postoperative recovery, and the author believes that the optimal operating time is the 21th day after preoperative high dose induced chemotherapy.
出处
《口腔颌面外科杂志》
CAS
1998年第4期242-244,共3页
Journal of Oral and Maxillofacial Surgery
基金
安徽省科委资助课题
