摘要
目的采用循证检验医学方法评价血清CysC水平变化是否可作为急性冠脉综合征诊断指标。方法检测ACS患者、ACS疑似患者、健康对照者血清中CysC的水平,同步检测ACS患者组、疑似组患者的CK-MB、hs-CRP,绘制此三种标志物用于诊断ACS的受试者特征曲线(ROC)曲线,并对标志物诊断准确度进行比较。结果ACS病人组的CysC浓度较对照组和疑似病人组低,其差异有统计学意义(P<0.05)。绘制ROC曲线得出AUC(CysC)为0.659(95%CI:0.522-0.795),AUC(hs-CRP)为0.622(95%CI:0.478-0.765),AUC(CK-MB)为0.674(95%CI:0.544-0.804),三者AUC差异无统计学意义。结论ACS患者存在CysC水平下降,但不适合作为ACS的诊断指标。
Objective To evaluate the clinical diagnostic value of Cystatin C in diagnosis of acute coronary syndrome （ACS）. Methods Serum level of Cystatin C was detected in ACS patients, suspected patients and health controls. Serum CK-MB and hs-CRP concentrations were measured in ACS patients and suspected patients. ROC curves of three markers were established respectively and compared. Results Compared with the health controls, the level of CysC was significantly lower in ACS patients （ P 〈 0.01 ）. Tne AUC （ CysC ） （0. 897） was significantly greater than 0.5 （ P 〈 0.001 ）. The AUCs of the three markers were： AUC （CysC） 0.659 （95 % CI： 0.522 - 0.795 ）, AUC （ hs- CRP ） 0. 622 （95 % CI： 0. 478 - 0. 765 ）, AUC （ CK- MB） 0. 674 （95 % CI： 0. 544 - 0. 804）, and they had no difference （ P 〉 0.05）. Conclusion The change of serum level of Cystatin C in ACS patients isn＇ t helpful to the diagnosis of ACS.
出处
《中国实验诊断学》
北大核心
2010年第3期429-431,共3页
Chinese Journal of Laboratory Diagnosis
基金
广州医学院教育学研究项目(2008-42)
关键词
急性冠脉综合征
胱抑素C
ROC曲线
循证医学
acute coronary syndrome
Cystatin C
ROC curve
evidence-based laboratory medicine
