摘要
目的探讨缬沙坦对压力负荷增高性心力衰竭(CHF)模型大鼠心肌重塑的影响。方法采用腹主动脉缩窄法建立CHF模型,随机分为治疗组和模型组,另设同源WKY大鼠为假手术组,每组10只。治疗组口服缬沙坦15 mg/(kg.d),6周后处死所有大鼠,比较各组大鼠心脏左心室质量指数、心肌间质纤维化程度及胶原含量。结果与假手术组比较,模型组大鼠左心室质量指数、心肌胶原含量均明显增加(F=149.02、5.27,q=23.65、4.27,P<0.01);应用缬沙坦6周后,与模型组比较,治疗组大鼠左心室质量指数、心肌胶原含量均显著减少(q=17.07、3.60,P<0.01)。结论缬沙坦能够逆转CHF模型大鼠心肌的重塑,从而阻止和延缓心力衰竭发生发展。
Objective To investigate the effects of valsartan on ventricular remodeling in rats with pressure overload-induced heart failure. Methods Rat models of congestive heart failure （CHF） were created by coarctation of aorta, which were randomized to treatment group, model group and sham operative group, with 10 rats in each group. The rats in treatment group were given valsartan （15 mg daily）, and all the rats killed after 6 weeks. The left ventric-ular mass index （LVMI） was calculated and myocardial collagen concentration measured. Results Compared with the sham operation group, there was significant in crease in I.VMI and myocardial collagen concentration in model group （F=149.02,5.27;q= 23.65,4.27;P〈0.01）. After 6 weeks of treatment, LVMI and myocardial collagen concentration in the therapy group was significantly decreased compared with the model group （q=17.07,3.60;P〈0.01）. Conclusion Valsartan can block and delay the development of CHF by reversing ventricular remodeling.
出处
《青岛大学医学院学报》
CAS
2010年第1期13-14,18,共3页
Acta Academiae Medicinae Qingdao Universitatis
