摘要
目的:探讨定量超声诊断早期类风湿性关节炎(RA)病人骨量变化的临床应用价值。方法:采用跟骨超声仪测量早期RA病人30例及与其相匹配的健康人30例的双足跟骨,主要诊断参数包括宽带超声振幅衰减(BUA)、超声传导速度(SOS)和超声硬度指数(STI),对两组的测量参数进行比较,并同时分析RA者骨质疏松发生率。结果:RA组BUA和STI明显低于对照组(均P﹤0.01),差异有显著性;而SOS和OP发生率与对照组比较差异均无统计学意义(均P﹥0.05);两组左右跟骨的BUA、SOS及STI比较差异均无统计学意义(P﹥0.05)。RA病人中活动组BUA及STI值显著低于非活动组(均P﹤0.01),SOS两组间比较差异无显著性(P﹥0.05)。结论:跟骨定量超声BUA测值减低可反映早期RA骨量丢失的程度及评价疾病的活动性。STI作为骨质量的综合评价指标,对早期RA病人的骨量丢失也有一定的意义。
Objective： To investigate the clinical application value of quantitative ultrasound that was used to diagnose bone quality changes in patients with early rheumatoid arthritis （RA）. Methods： Broadband ultrasound attenuation （BUA）, Speed of sound （SOS） and Stiffness index （STI） were measured by quantitative ultrasound in 30 RA patients and the results were compared with age-, sex- ,BMI-marched healthy people. Meanwhile, analyzing the incidence of OP in patients with early rheumatoid arthritis. Results： BUA and STI in RA patients were both lower than those in healthy people （P 〈 0.01）. SOS and the incidence of OP had no statistical significance between RA patients and the control group （P 〉 0.05）.The QUS （quantitative ultrasound） results of bilateral calcaneus had no significant differences （P 〉 O.05）.BUA and STI in active group were significant lower than those in non-active group （P 〈 0.01）, SOS had no statistical significance between the two groups （P 〉 0.05）. Conclusion： BUA could reflect bone loss degree and evaluate disease activity in early RA patients.As a comprehensive index,STI has some meaning to bone loss in the early RA patients.
出处
《天津医科大学学报》
2010年第1期163-165,共3页
Journal of Tianjin Medical University
关键词
类风湿关节炎
定量超声
骨量变化
骨质疏松
Rheumatoid arthritis
Quantitative ultrasound
Bone quality changes
Osteoporosis
