摘要
目的探讨豆制品、豆腐和酱汤摄入与胃癌的相关性。方法检索1988-2008年间中英文发表的再制品、豆腐和酱汤摄入与胃癌发生相关的流行病学文献，共检索到53篇，纳入28篇。利用Meta分析进行定量评价：结果28篇文献中16篇为病例对照研究，10篇为队列研究，另外2篇为横断向研究。由于各研究间存存异质性，故采用随机效应模型进行分析。结果显示，豆制品、豆腐和酱汤与胃癌发生的合并OR值（95％CI值）分别为：0．58（0．52～0．65）、0．90（0．80～1．00）和1．18（1．09～1．28）。漏斗罔显示文献不存在明显的发表偏倚，所得结论没有因为灵敏度分析而改变。结论豆制品和豆腐的摄入可减少胃癌发病的危险，酱汤摄入则增加了胃癌发病的危险。
Objective To study the effects of soybean products consumption on the risk of gastric cancer. Methods Literatures published in English and Chinese reporting the relationship between soybean product consumption and gastric cancer from 1988 to 2008 were searched in this study. Fifty-three relevant articles were selected and 28 of them met the criteria. Meta-analysis was applied to estimate the combined odds ratio （OR） and 95% confidence interval （95% CI） between soybean product consumption and gastric cancer. Results A total of 28 independent studies were selected including 16 case-control studies,10 cohort studies and 2 cross sectional studies. The random-effect model was used due to the heterogeneity among these studies. The overall ORs （95% CI） of Meta-analysis on subjects who consumed soybean products, tofu and miso were 0. 58 （ 0. 52 - 0. 65 ） , 0. 90 （ 0. 80 - 1.00 ） and 1.18 （ 1.09 - 1.28 ） , respectively. Conclusion Consumption of soybean products and tofu was inversely associated with gastric cancer, while miso consumption could increase the risk to gastric cancer.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2010年第3期215-220,共6页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金（30771808）
