摘要
甲苯氯化反应在L酸催化下,加入助催化剂可以调节邻氯甲苯和对氯甲苯比率。合成了三种不同结构杂环苯并硫氮杂卓化合物助催化剂。以SbCl3为催化剂,分别用三种不同结构苯并硫氮杂卓化合物为助催化剂,考察了甲苯定向氯化对氯甲苯选择性的影响;得出最高选择性助催化剂后,找出温度和催化剂用量等工艺条件,使甲苯定向氯化对氯甲苯与邻氯甲苯物质的量之比达到1.29。
Ring-chlorination of toluene is usually carried out in the presence of Lewis acids and co-catalysts that can increase the ratio of p-/o- isomers. In this paper, the synthesis of three benzothiazepines derivative compounds are reported. The ring-chlorination of toluene using SbCl3 as a catalyst and benzoth- iazepines derivatives as co-catalysts at different temperature and different dosage of co-catalyst were stuied. All of the compounds can increase the p-/o- ratio in the reaction. Among them N-（2,3-dihydro-1,5- benzothiazepine-4yl）-hydroxylamine exhibited the best co-catalytic results that gave p-/o-ratio of 1.29.
出处
《工业催化》
CAS
2010年第1期66-69,共4页
Industrial Catalysis
关键词
催化化学
助催化剂
苯并硫氮杂卓
甲苯定向氯化
catalytic chemistry
co-catalyst
benzothiazepine
toluene ring-chlorination
