摘要
Meta分析是系统综述中数据的定量统计分析方法,目前已涌现出一些关于Meta分析在药物流行病学中的研究,Meta分析应用于药品不良反应有其独特优势。通过介绍Meta分析的概念、研究步骤,结合噻唑烷二酮类药物引起的心血管事件、药品不良反应发生率及种族差异间的Meta分析实例,指出在药品不良反应信号检测的Meta分析时,应注意灵敏度分析、亚组分析及选择正确的模型。
Meta-analysis is a statistical technique for summarizing previous quantitative research with its unique advantages. In this article we gave a brief introduction about the concept, steps about meta-analysis. And also illustrated several examples including cardiovascular events caused by TZDs, the incidence of adverse drug reactions（ADR） in hospitalized patients and ethnic differences in risks of adverse reactions. In addition, we also suggested that sensitive analysis, sub-group analysis and model selection should not be ignored while applying Meta-analysis in ADR signal detection.
出处
《中国药物警戒》
2010年第3期148-150,共3页
Chinese Journal of Pharmacovigilance
基金
国家自然科学基金资助项目(No.30872186)
上海市优秀学科带头人计划(A类)(No.09XD1405500)
