摘要
目的探讨甲胎蛋白（AFP）含量及其动态变化与慢加急性肝功能衰竭预后的关系。方法对78例慢加急性肝功能衰竭患者进行回顾性分析，依据病情将患者分为早、中、晚三期，患者均给予内科常规治疗，根据治疗结果将各期患者分为存活组与死亡组。分析两组患者AFP、总胆红素（TBiL）、凝血酶原活动度（PTA）的峰值及其动态变化对患者预后的影响。结果慢加急性肝功能衰竭早期和中期患者存活组AFP和VIA的峰值明显高于死亡组（P〈0．05），TBiL的峰值存活组显著低于死亡组（P〈0．05），而晚期患者的AFP、TBiL和PTA的峰值存活组和死亡组间无统计学意义。AFP上升和／或TBiL下降对早、中、晚期患者预后的敏感性均为100％，特异性分别为86％、71％和50％。结论慢加急性肝功能衰竭患者血清AFP含量升高反映肝细胞再生活跃，提示预后良好。
Objective To investigate the relationship between the alpha-fetoprotein（AFP） value changes and prognosis in acute on chronic liver failure. Methods 78 cases of acute on chronic liver failure patients were retrospectively analyzed. All the patients were divide into three stages ： ealy stage, medium-term stage, advanced stage. In every stage, according to the final results the patients were divided into survival group and death group. Maximum values of the AFP, TBiL and PTA were analyzed in the two groups, and their value changes were used to prognose of acute on chronic liver failure. Results In ealy stage and medium-term stage the maximum values of the AFP and PTA were significantly higher in survival group than that in death group, and the maximum values of TBil was significantly lower in survival group than that in death group. However,in advanced stage the maximum values of the AFP, TBiL and PTA have no significant difference. The increasing AFP and/or decreasing TBiL levels predict well outcome of acute on chronic liver failure, which sensitivity were 100% in all stages and specificity were respectively 86% ,71% , 50% in the ealy stage,medium-term stage and advanced stage. Conclusion Our observations suggest that rising level of AFP and decreasing level of TBiL frequently indicated survival.
出处
《中国基层医药》
CAS
2010年第3期315-316,共2页
Chinese Journal of Primary Medicine and Pharmacy
