摘要
抗结核药肝损害、视神经损害、血液学异常及胃肠反应的发生率较高,用药监护不当可能引发医疗纠纷。因乙胺丁醇引起患者双目失明、利福平引起过敏死亡,引发两起用药纠纷。抗结核药物安全性低,医务人员要及时监护。用药前做痰涂片、抗酸菌检查,并尽可能做药敏实验,以决定选药;用药前和用药期间应定期监测患者的肝功能、肾功能、视力及各项生理指标。抗结核药物出现严重药品不良事件,要立即停止治疗,给予相应救治措施,医师、护士、临床药师都有责任对患者实时监护,减少用药风险。
Liver injury, optic nerve damage, hematological abnormalities and gastrointestinal reaction induced by antituberculous agents show high frequency. Inappropriate monitoring of medicine leads to many medical disputes. In Zhejiang and Jiangxi provinces, blindness induced by ethambutol, allergenic death induced by rifampiein caused two cases of medical dispute. Medical staff should use antituberculous agents reasonably, give proper monitoring timely, regularly check and monitoring the patient's liver function, kidney function and various physiological examine before and during the chemotherapy. The results of sputum smear, the examine of acid-fast basillus of the sputum and drug sensitivity test must be obtained before drug taking. Irregular drug taking causes serious adverse reactions. Antituberculous agents should be stopped immediately whenever serious adverse reactions occur. Pediatricians, nurses and pharmacists should strengthen monitoring of medicine to protect patients.
出处
《药学与临床研究》
2010年第1期20-23,共4页
Pharmaceutical and Clinical Research