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凝血、抗凝血以及纤溶系统与荨麻疹发病的关系 被引量:6

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摘要 用酶联免疫吸附法检测荨麻疹患者和正常对照者血浆D-二聚体、FVⅡa、TFPⅠ/Xa的水平,并分析其与症状评分、病程的关系。为得到更为准确可靠的结果,进行前后两次实验并作综合分析。在两次实验中,急性荨麻疹和慢性荨麻疹患者血浆D-二聚体水平均明显高于正常对照(P<0.01),且D-二聚体水平与症状评分呈正相关(r=0.82,P<0.01)。但FVⅡa和TFPⅠ/Xa水平在两次实验结果中不一致:实验1,急性荨麻疹和慢性荨麻疹患者FVⅡa水平较正常对照者低(P<0.01),TFPⅠ/Xa水平在急性荨麻疹和慢性荨麻疹患者以及正常对照组中差异无统计学意义(P>0.05)。而在实验2,急性荨麻疹FVⅡa水平及慢性荨麻疹TFPI/Xa水平均高于正常对照(均P<0.01)。本研究结果显示:荨麻疹患者存在凝血级联反应的激活,抗凝和继发性纤溶也参与荨麻疹的发病。但在不同疾病阶段部分相关的蛋白因子水平处在动态水平。
出处 《中国麻风皮肤病杂志》 2010年第2期102-104,共3页 China Journal of Leprosy and Skin Diseases
基金 2007年广州市医药卫生科技项目(2007-YB-146)
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参考文献10

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同被引文献46

  • 1刘小明,盛晚香,周芬,周武.地氯雷他定联合潘生丁治疗慢性荨麻疹疗效观察[J].中国皮肤性病学杂志,2007,21(7):443-444. 被引量:7
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