摘要
目的探讨子宫内膜异位症（EMS）患者血清雌二醇（E2）、肿瘤坏死因子（TNF）-d和血管内皮生长因子（VEGF）的临床意义。方法选择EMS患者59例（EMS组），检测患者术前24h、术后7d及术后6个月随访时的血清E2、TNF-α和VEGF，并与同期健康查体的育龄妇女60例（对照组）进行比较。结果EMS组术前血清E2、TNF-α和VEGF[（216．5±59．7）ng／L、（30．4±17．5）μg/L、（250．7±88．7）ng／L]均明显高于对照组[（100．2±33．2）ng／L、（11．2±3．6）μg／L、（103．2±49．2）ng／L]及术后[（121．3±44．6）．g／L、（13．4±6．2）μg/L、（153．9±58．7）．g／L]（P〈0．01）；而EMS组术后血清E：、TNF-α和VEGF与对照组比较差异均无统计学意义（P〉0．05）。EMS组Ⅲ～Ⅳ期患者血清E2、TNF-α和VEGF[（316．5±77．6）ng／L、（51．1±12．3）-αg／L、（305．1±69．7）ng／L]均显著高于对照组和I。Ⅱ期患者[（170．74-48．2）ng／L、（25．8±10．1）μg，L、（169．2±36．1）ng／L]（P〈0．05或〈0．01）；I～Ⅱ期EMS患者血清E：、TNF-α和VEGF高于对照组（P〈0．05）。EMS患者术后6个月随访时有9例复发，50例未复发。复发患者血清E2、TNF-α和VEGF[（187．8±46．7）μg／L、（23．9±9．5）μg/L、（185.3±57．4）ng／L]显著高于对照组（P〈0．01）；未复发患者血清E2、TNF-α和VEGF[（112．7±30.3）ng/L、（13．2±4．7）μg／L、（116．4±30．3）ng,／L]与对照组比较，差异无统计学意义（P〉0．05）。结论血清E2、TNF-α和VEGF可能在EMS的发生、发展中起重要作用。检测EMS患者血清E2、TNF-α和VEGF对病情和预后判断均有重要的临床意义。
Objective To detect the level of the serum estradiol-2 （E2）, tumor necrosis factor-alpha （TNF-α） and vascular endothelial growth factor （VEGF） in patients with endometriosis （EMS） and explore their clinical significance. Methods Fifty-nine EMS patients from January 2006 to January 2009 were selected as EMS group and 60 normal women were selected as control group. The serum E2,TNF-α and VEGF in EMS group 24 h pre-operation, 7 d post-operation and 6 months after operation were detected, and compared with control group. Results The levels of the serum E2[ （216.5 ± 59.7 ） ng/L], TNF- α [ （30.4 ± 17.5） μg/L] and VEGF [（250.7 ± 88.7） ng/L] in EMS group pre-operation were significantly higher than those in control group [（100.2 ± 33.2） ng/L, （11.2 ± 3.6） μg/L, （103.2 ±49.2） ng/L] and post-operation [（121.3 ±44.6） ng/L, （13.4 ±6.2） μg/L,（153.9 ±58.7） ng/L] （P〈0.O1）. But there was no significant difference between control group and post-operation of EMS group （P〉 0.05）. The levels of the serum E2 [ （316.5 ± 77.6） ng/L ], TNF-α [ （51.1 ± 12.3 ） IX g/L ] and VEGF [ （ 305.1 ± 69.7 ） ng/L ] with stage llI- 1V in EMS group were higher than those in control group or those with stage Ⅰ-Ⅱ[（170.7 ±48.2） ng/L, （25.8 ± 10.1） IXg/L, （169.2 ±36.1） ng/L] （P 〈0.05 or 〈0.01）. The levels of the serum E2,TNF-ot and VEGF with stage Ⅰ-Ⅱ in EMS group were also higher than those in control group （P 〈 0.05 ）. Nine patients recurred at 6 months after the operation. The levels of the serum E2[ （187.8 ± 46.7 ） ng/L], TNF-α [ （23.9 ± 9.5） μg/L] and VEGF [ （ 185.3 ± 57.4） ng/L] of the recurred EMS patients stepped up significantly higher than those of the non-recurred EMS patients [ （ 112.7 ± 30.3 ） ng/L, （ 13.2 ± 4.7） μg/L, （ 116.4 ± 30.3 ） ng/L] （P 〈 0.01 ）. While there was no significant difference between control group and non-recurred EMS patients （P 〉0.05）. Conclusions
出处
《中国医师进修杂志》
2010年第3期23-26,共4页
Chinese Journal of Postgraduates of Medicine
