摘要
目的探讨甲亢患者甲状腺激素水平与血脂代谢指标变化的关系。方法对165例甲亢患者治疗前后的甲状腺激素(TH)水平、血脂水平进行对照分析。结果甲亢治疗前后与健康对照组比较,游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、明显增高,促甲状腺激素(TSH)明显降低,差异有统计学意义(P<0.01);总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(LDL-C)、低密度脂蛋白胆固醇(HDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)均明显降低,且差异具有统计学意义(P<0.01);HDL-C无明显变化(P>0.05)。结论甲状腺激素与脂类的代谢密切相关,临床上在诊治甲亢患者时,应适当加强血脂水平的监测,这对疾病的发展、预后判断很有价值。
Objective To study the relationship between the level of serum thyroid hormone and the indexes changes of lipid metabolism in the patients with hyperthyroidism. Methods The levels of serum free T3 （FT3）, free T4 （FT4）, and higher-thyrotropin（TSH） were measured by RIA in 165 cases. Serum total eholeslerol（TC）, triglycerides（TG） ,high density lipoprotein（HDL-c）,low density lipoprotein（LDL-c）,apolipoprotein A（ApoA- I ）and apolipoprotein B（Apo B）concentrations were simultaneously determined. The correlation of these targets between pre-and post-treatment was analyzed. Results In pre-treatment,the levels of serum FT3 and FT4 were significantly higher, TSH was significantly lower than those in post-treatment and control group （P〈0.01）. The levels of serum TG, Teh, LDL-c, ApoA- I and Apo B were significantly lower between post treatment and control group （P〈0.01） The levels of serum HDL c was not different than post-treatment and control group（P〈0.05）. Conclusion There is a close correlation of the serum thyroid hormone level reduces with the lipid metabolism, serum thyroid hormone deficiency may be one of the important reasons raising blood lipid level in the patients with hyperthyroidism. Determining the level of serum thyroid hormone in the patients with hyperthyroidism has certainly clinical value to evaluate,treat and prognosis.
出处
《检验医学与临床》
CAS
2010年第4期317-318,共2页
Laboratory Medicine and Clinic
