摘要
目的探讨胰腺腺泡细胞癌的组织学特点、生物学特征、治疗方法及预后。方法回顾性分析1999至2008年间收治的10例胰腺腺泡细胞癌患者的临床特点、影像学改变、病理学特征、治疗经过及随访资料。结果10例胰腺腺泡细胞癌患者中男9例，女1例，平均年龄（62±8）岁。CT检查示肿瘤位于胰腺钩突部1例，胰头7例，胰体尾2例；肿瘤大小平均为4．5cm×4．7cm；7例胆总管和肝内胆管明显扩张、胰管扩张；2例侵犯肠系膜上静脉。行胰头十二指肠切除术8例，其中3例合并扩大淋巴结清扫术，2例合并门静脉切除置换；2例行胰体尾＋脾切除。病理检查示瘤体平均4．0cm×3．3cm×3．4cm；镜下见5例胰头肿瘤侵犯十二指肠，2例侵犯肠系膜上静脉；7例肿瘤侵犯神经；6例淋巴结转移。随访9例，1例失访。术后存活3～51个月，平均存活18个月，均死于肿瘤复发和转移。结论胰腺腺泡细胞癌是胰腺一个独立的高度恶性的类型，对放化疗可能都不敏感，其生物学特征有待进一步研究。
Objective To investigate the histological features, biological features, clinical treatment and prognosis of pancreatic acinar cell carcinoma. Methods A retrospective review of 10 patients with pancreatic acinar cell carcinoma treated in our hospital from 1999 to 2008 was conducted and the clinical features, imaging changes, pathologic feature, treatment course and follow-up data were collected. Results There were 9 men and 1 woman with a mean age of （62 ± 8） years old. Tumors were located in the uncinate process in 1 patient, head of pancreas in 7, body and tail in 2. The median size of these tumors was 4.5 cm× 4.7 cm; common bile duct and intrahepatic bile duct, pancreatic duct dilation was detected in 7 cases, and superior mesenteric vein was invaded in 2 cases. Of the l0 patients, 8 received pancreaticoduodenectomy, among these 8 patients, 3 had extended lymph node dissection, 2 had portal vein resection and replacement; 2 received resection of pancreatic body and tail as well as splenectomy. Histologically, the size of these tumors were 4.0 cm× 3.3 cm × 3.4 cm. Macroscopically, duodenum was invaded in 5 patients, superior mesenteric vein was invaded in 2 patients and neural invasion was present in 7 cases. Lymph node metastasis was noted in 6 cases. Follow-up data was available in 9 patients and 1 patient was lost in follow-up. The survival ranged from 3 to 51 months with a median survival 18 months, and 9 patients died of tumor recurrence and metastasis after operation. Conclusions Pancreatic acinar cell carcinoma should be recognized as a distinct tumor entity and it may not be sensitive to radiotherapy or chemotherapy. The biological features of pancreatic acinar cell carcinoma should be investigated further.
出处
《中华胰腺病杂志》
CAS
2010年第1期6-8,共3页
Chinese Journal of Pancreatology
关键词
胰腺
癌
腺泡细胞
诊断
治疗
预后
Pancreas
Carcinoma, acinar cell
Diagnosis
Therapy
Prognosis
