摘要
目的:观察泥胡菜的抗炎作用。方法:采用二甲苯致小鼠耳肿胀法、大鼠棉球肉芽肿法、大鼠尿酸盐结晶所致痛风性关节炎模型,观察泥胡菜的抗炎作用,并采用甲醛致小鼠足肿胀法观察其对炎症局部组织中前列腺素(PGE2)的影响。结果:泥胡菜能明显抑制二甲苯所致的小鼠耳肿胀,减少大鼠棉球肉芽肿的形成,对微晶型尿酸钠致大鼠踝关节肿胀有显著抑制作用,降低炎性组织中PGE2的含量。结论:泥胡菜具有明显抗炎作用,其机制与抑制组织中PGE2生成有关。
Objective To study the anti-inflammatory activities of the ethanol extract of Hemistepta lyrata Bunge. Methods The methods of xylene-indueed ear edema in mice, granuloma induced with cotton ball in rats and hind paw edema induced with crystallite sodium urate in rats were used to observe the anti-inflammatory effects. The content of PGE2 was measured in hind paw edema induced with formaldehyde in mice. Results Tile ethanol extract of H. lyrata Bunge. could inhibit xylene-in- duced ear edema, granuloma induced with cotton ball and hind paw edema induced with crystallite sodium urate in rats, de- crease the content of PGE2. Conclusion The ethanol extract of tt. lyrata Bunge. has significant anti-inflammatory effects, which was related to its inhibitory effects on PGE2.
出处
《中医药导报》
2010年第2期59-61,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
广东药学院引进人才科研基金(2007ZYX02)
关键词
泥胡菜
抗炎
前列腺素
Hemistepta lyrata Bunge.
anti-inflammatory
PGE2
