摘要
目的:探讨氯氮平剂量、血药浓度和临床疗效间的相互关系。方法:氯氮平治疗精神分裂症共210例,统计患者年龄、性别、服药剂量、血药浓度、各项检查结果、临床疗效及不良反应,并进行分析。结果:男女二组血药浓度组间有显著性差异(P<0.05),氯氮平的剂量与血药浓度有相关性(r=0.6350),高、中、低剂量的血药浓度有显著性差异(P<0.05),血药浓度小于300ng/ml显效率低,高于600ng/ml患者疗效并不增加,不良反应反而加重。结论:临床应根据血药浓度监测结果及临床症状调整给药剂量以提高疗效,减少不良反应。
Objective： To discuss the relationship among the dose and plasma concentration of clozapine and clinial efficacy. Method： 210 cases with schizophrenia were treated by clozapine. Patients＂ age, sex, dosage, plasma concentration, examination results, clinical efficacy and adverse reactions were summarized and analyzed. Result： Men＇s plasma concentration is obviously dif- ferent from womens＂ （P〈0.05）; there has correlation between the dosage and plasma concentration of clozapine （r= 0. 6350）; plasma concentrations are obviously different in high, medium and low dosage （P〈0.05）; patients whose plasma concentration lower than 300ng/ml have low obvious effective rate, and for those whose plasma concentration higher than 600ng/ml have severe adverse reactions. Conclusion.. We should adjust the dosage according to the determination results of plasma concentration and clinical symptoms so as to improve the efficacy and reduce the adverse reactions.
出处
《内蒙古中医药》
2010年第1期25-27,共3页
Inner Mongolia Journal of Traditional Chinese Medicine
关键词
氯氮平
血药浓度
Clozapine
Plasma concentration
