摘要
目的研究握力刺激强度与运动皮层激活程度的相关性。方法16例正常右利手受试者根据视觉刺激提示右手进行固定频率的三种不同握力运动,同时进行BOLD fMRI扫描,用spm5计算得到不同握力的脑激活区并比较差异。结果在三种不同握力运动中,对侧主运动区、对侧躯体感觉区、对侧辅助运动区(SMA)和对侧运动前区(PMC)明显激活;同侧激活区较小或者未见激活区;同侧小脑激活区较对侧明显激活。随着握力强度的增高,M1和S1激活强度、范围都提高;小脑激活程度有所降低。结论正常人手握力运动时脑皮质运动网络被激活,握力刺激强度与M1、S1的激活程度呈正相关。
Objective To study the brain functional activations under several grip force levels. Methods Functional MRI was performed in 16 healthy subjects who alternated between rest and squeezing rubber O-ring task at fix frequency （ 1 Hz） at one of three force levels using right hand. Statistic the brain functional activations under different grip force levets and compare the results using spm5 software. Results For each force level, group analysis results revealed that the contralateral sensorimotor cortex（SMC） , supplementary motor area （SMA） , pre-motor area （PMC） were activated, and the ipsilaterals were smaller or none. Bilateral cerebellum were activated, and the ipsilateral was stronger. Increased force of squeezing is associated with increased contralateral sensorimotor cortex, but decreased cerebellum. Conclusion Cerebral cortical motor network was extensively activated during grip force movement in normal subjects. Motor cortex neurons show increased activity with increased force of movement.
出处
《北京生物医学工程》
2010年第1期30-34,共5页
Beijing Biomedical Engineering
基金
国家自然科学基金(30670576)资助
关键词
功能磁共振成像
O形橡胶圈
握力
脑运动皮层
小脑
functional magnetic resonance imaging
rubber O-ring
grip force
brain motor cortex
cerebellum
