摘要
目的研究染色体9p21上rs10757278位点单核苷酸多态性(SNP)与中国汉族人群心肌梗死患病的相关性。方法选取432例初发心肌梗死患者(MI组)及430例同期住院的外科对照患者。采用PCR-SNPStream技术对rs10757278位点进行多态性分型。并对分型结果进行统计学分析。结果在MI组,rs10757278位点的GG、AG基因型分布频率高于对照组,G等位基因分布频率也高于对照组(P<0.01)。经校正混杂因素的影响后,我们发现rs10757278位点G等位基因的单个拷贝使MI发生的风险分别提高了33%(P<0.05)。结论rs10757278是汉族人MI发生的易感位点。
Objective To investigate the correlation between rs10757278 single nueleotide polymorphism （SNP） on chromosome 9021 and myocardial infarction in Chinese Hans. Methods 432 patients with myocardial infarction and 430 controls were involved. PCR- SNP Stream platform were used to genotyping SNP. Advanced analysis was performed. Results The frequency of genotype GG, AG and allele G of rs10757278 were increased in MI group, compared with control group （P〈0. 01）. After adjusted the confounding factors, we found the allele G increased the risk suffer MI by 33%. Conclusion rs10757278 is the susceptible locus to MI in Chinese Hans.
出处
《中国煤炭工业医学杂志》
2010年第2期173-174,共2页
Chinese Journal of Coal Industry Medicine
基金
国家自然科学基金资助项目(30971237)
唐山市科技局基金资助项目(09130202A-3-23)
关键词
遗传
染色体
单核苷酸多态性
心肌梗死
genetic
ehromatosome
single nueleotide polymorphism
myoeardial infarction
