摘要
目的:通过宁心律康颗粒对乌头碱诱发的大鼠心律失常模型以及对冠状动脉结扎诱发的犬心律失常模型的作用,研究宁心律康的抗心律失常的作用。方法:①一次静注乌头碱复制大鼠心律失常模型,记录出现室性早搏、室性心动过速的出现时间以及心室颤动的发生率。②结扎犬冠状动脉左前降支1/3处复制犬心律失常模型,记录心律失常的潜伏期、出现心律失常后的心电图心律失常评分以及室性心动过速和心室颤动的发生率。结果:①宁心律康能明显推迟大鼠室性早搏、室性心动过速的出现时间,减少心室颤动的发生率;②宁心律康能明显推迟犬冠状动脉结扎后心律失常的出现时间,减少心律失常的分值以及降低室性心动过速和心室颤动的发生率。结论:宁心律康具有良好的抗实验性心律失常作用。
Objective： To obeserve NXLK granule＇ s effect of anti-arrhythmia through the aonitine-induced arrhythmia model in rats, as well as coronary artery ligation induced arrhythmia model of the dogs. Methods ： Intravenous injection aconitine copy arrhythmia model in rats, record the appear times of ventricular premature and ventricular tachycardia, as well as the emergence rate of ventricular fibrillation. Ligate left anterior descending coronary artery copy arrhythmia model in dogs, record the incubation period of arrhythmia, after the emergence of arrhythmia, calculate the ECG score, count the incidence of ventricular tachycardia and ventricular fibrillation. Results ： The NXLK granule could significantly delay the emergence time of rat＇ s ventricular premature and ventricular taehyeardia, and reduce the incidence of ventricular fibrillation;The NXLK granule could significantly delay the emergence time of dog＇s arrhythmia induced by ligate left anterior descending coronary artery, reduce the arrhythmia score and reduce the incidence of ventricular taehycardia,ventricular fibrillation. Conclusion：NXLK granule has anti-arrhythmic effects against experimental arrhythmia.
出处
《江西中医学院学报》
2009年第6期66-68,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
