摘要
目的:探讨绝经前后乳腺癌患者血清中胰岛素样生长因子-I(IGF-I)的表达及临床意义。方法:采集68例乳腺癌患者(绝经前43例,绝经后25例),22例乳腺良性疾病(绝经前15例,绝经后7例),16例健康体检者(绝经前9例,绝经后7例)血液样本,用酶联免疫吸附法检测乳腺癌组、乳腺良性疾病组及正常对照组血清IGF-I的浓度。结果:乳腺癌组血清中IGF-I含量高于乳腺良性疾病组和正常对照组(P<0.05);乳腺良性疾病组与正常对照组无统计学差异(P>0.05);乳腺癌组血清中IGF-I浓度绝经前高于绝经后(P<0.05)。结论:IGF-I在乳腺癌患者中具有高表达趋势,并且绝经前乳腺癌患者血清IGF-I浓度高于绝经后。提示IGF-I可能在乳腺癌的发生和演变中起重要作用。
Objective： To explore the expression and significance of insulin - like growth factor - Ⅰ （ IGF - Ⅰ ） in serum in premenopausal and postmenopausal patients with breast cancer. Methods： Serum samples from 68 cases with breast cancer （43 cases during premenopausal period and 25 cases during postmenopausal period）, 22 cases with benign breast diseases （ 15 cases during premenopausal period and 7 cases during postmenopausal period）, 16 healthy women without breast diseases （control group, 9 cases during premenopausal period and 7 cases during postmenopansal period ） were collected, then the serum levels of IGF - Ⅰ in the three groups were detected by ELISA. Results： The serum level of IGF -Ⅰ in breast cancer group was higher than those in benign breast diseases group and control group （ P 〈 0. 05 ） ; but there was no significant difference between benign breast diseases group and control group （ P 〉 0.05 ） ; in breast cancer group, the serum level of IGF - Ⅰ during premenopausal period was higher than that during postmenopausal period （ P 〈 0. 05 ） . Conclusion： Patients with breast cancer own a high expression trend of serum IGF - Ⅰ, and the serum level of IGF -Ⅰ during premenopausal period is higher than that during postmenopausal period, which indicates that IGF - Ⅰ maybe play an important role in occurrence and evolvement of breast Cancer.
出处
《中国妇幼保健》
CAS
北大核心
2010年第6期759-760,共2页
Maternal and Child Health Care of China
关键词
乳腺癌
IGF—Ⅰ绝经
Breast cancer
Insulin- like growth factor- Ⅰ
Menopause
