摘要
为探讨肿瘤坏死因子-α（TNF-α）及其受体p55在结肠癌组织中的表达水平，以及其与肿瘤细胞分化程度的相关性，对32例结肠癌标本，采用免疫组化方法染色，观察TNF—α与其受体p55阳性率及表达强度，并分析其与肿瘤细胞分化程度的关系。结果显示，结肠癌组织TNF—α及受体蛋白p55表达阳性率分别为80．7％及67．7％，多为中等强度表达，TNF-α及p55表达与肿瘤细胞分化程度呈负相关。结果表明，TNF-α及其受体蛋白p55在结肠癌组织中存在高表达现象，其可能通过影响肿瘤细胞分化发挥抗肿瘤作用。
The objective of the study was to evaluated the correlation between the expression of tumor necrosis factor-α（TNF-α） and p55 of the colonic carcinoma tissues and tumor cell differentiation. The specimen from 32 patients with colonic carcinoma were included in the study. Immunohistochemical staining was used,the expression and positive rate of TNF-α and receptor p55 were observed, and the correlation of which with the tumor cell differentiation was analysed. As results,the positivity expression rates of TNF-α and p55 were 80.7% and 67.7% respectively（moderate expression in general） and TNF-α and p55 expressions with tumor cell differentiation were negatively correlated. It is concluded that high expression exists in TNF-α and p55 in colonic carcinoma tissues, which may anti-tumor by influence tumor cell differentia- tion.
出处
《中国肛肠病杂志》
2010年第1期9-11,共3页
Chinese Journal of Coloproctology
