摘要
目的探讨和分析孕妇风疹病毒感染与胎儿先天性心脏病（简称先心病）的关系，为提高先天性风疹综合征产前诊断率寻求方法。方法对超声心动图诊断并要求引产的38例先心病胎儿行脐带穿刺，采用酶联免疫吸附试验测定脐血风疹病毒特异性抗体IgM。结果38例先心病胎儿中18例脐血风疹病毒IgM（＋），占47．4％，其余20例IgM（-）。18例风疹病毒IgM（＋）胎儿按心脏异常结构出现频率排序：室间隔缺损10例、肺动脉发育异常9例、房室瓣异常6例、大动脉转位5例、主动脉骑跨4例。IgM（＋）和IgM（-）组中属于圆锥动脉分隔异常或圆锥动脉干间隔旋转不足或方向相反的病例数分别为11例（61．1％）和5例（25．0％）（P〈0．05）。结论风疹病毒与胎儿先心病的发生有一定关联，可能影响胎儿心室分隔和圆锥动脉干发育。B超提示胎儿室间隔缺损、肺动脉发育异常、心肌瓣膜异常、大动脉转位时，应考虑到风疹病毒感染的可能。
Objective To investigate the fetal congenital heart diseases （CHD） caused by rubella virus infection, and to explore the methods for prenatal diagnosis of congenital rubella syndrome. Methods The rubella virus-specific IgM of cord blood were tested by ELISA in 38 fetuses with CHD detected by eehocardiography after which the pregnancies were terminated. Results Eighteen （47.4 %） out of the 38 fetuses showed IgM（＋） and 20 were IgM（-）. The most common seen cardiac abnormalities in the 18 IgM（＋） cases were ventricular septal defect （n= 10）, pulmonary artery dysplasia（n= 9）, abnormal atrioventricular valves（n= 6）, transposition of the great arteries （n=5） and aortic saddle（n=4）. The number of cases with congenital eonotruncal defects in IgM（＋） and IgM（-） groups were 11（61.1%） and 5（25.0%）, respeetively（P〈0.05）. Conclusions Rubella virus may influence the development of fetal ventricles and conotruncus. Ultrasound detection of ventricular septal defect, pulmonary artery dysplasia, abnormal heart valves, transposition of the great arteries should alert the clinicians of rubella virus infection.
出处
《中华围产医学杂志》
CAS
2010年第1期9-11,共3页
Chinese Journal of Perinatal Medicine
基金
北京市科技计划基金（D0906005000091）
关键词
心脏缺损
先天性
风疹病毒感染
胎儿疾病
Heart defects, congenital
Rubivirus infections
Fetal diseases
