摘要
FOXM1（Forkhed box M1），Forkhead转录因子家族中的一员，有3个亚型，即FOXM1a、FOXM1b、FOXM1c，目前的研究集中在FOXM1b、FOXM1c。FOXM1通过调节细胞增生相关基因的转录，在胚胎发育、组织再生的过程中发挥着关键性的功能。近来研究证明，FOXM1与肿瘤的发生、发展密切相关，FOXM1高表达的肿瘤往往呈低分化、高度恶性、远处转移，临床预后不佳。FOXM1通过对其下游肿瘤相关基因的表达调控，涉及肿瘤的增生、侵袭、转移及血管生成。目前，以FOXM1为靶点的抗肿瘤化学物质的合成及研究，为FOXM1的开发应用提供了可能。FOXM1在肿瘤治疗中价值成为当前国内外的研究热点。现对FOXM1在肿瘤学方面的研究进展进行综述。
FOXM1 （Forkhead box M1 ）, one factor of the Forkhead family, has three subtypes （FOXMla, FOXMlb, FOXMlc）. The current study focuses on FOXMlb and FOXMlc. FOXM1 regulates transcription of proliferation-associated genes and plays a vital role in embryogenesis as well as reorgani- zation. Recent studies have shown that FOXM1 is closely related with tumor occurrence and development. Tumors with high expression of FOXM1 are often poorly differentiated, highly malignant, distantly metastat- ic, poorly predicted. FOXM1 has a influence on the tumor proliferation, invasion, metastasis and angiogenesis through regulating its downstream tumor-related genes. At present, the synthesis and study of the antitumor chemicals targeting FOXM1 offer a possibility of the FOXM1 in clinical applications. More and more researchers attach importance to its tumor therapeutic value both at home and aboard. This paper will make a review about the lastest FOXM1 research in oncology.
出处
《国际外科学杂志》
2010年第2期131-135,共5页
International Journal of Surgery
关键词
FOXM1
转录因子
肿瘤
Forkhead box M1
Transcription factor
Tumor
