摘要
目的探讨炔诺酮对无排卵性功能失调性子宫出血患者的临床症状、子宫内膜和性激素的影响。方法选取2005年6月至2008年6月病理诊断子宫内膜单纯增生患者120例,于分段诊刮术后第5天及下两次月经周期第5天给予炔诺酮治疗,共3个周期,观察经期、经量、月经周期、子宫内膜和血清性激素变化。结果炔诺酮治疗前后性激素水平比较,差异无统计学意义(P>0.05);治疗3个周期后,患者治疗前出血时间(21.37±0.56)d缩短到治疗后(6.43±0.90)d,差异有统计学意义(P<0.05),并且经量减少(P<0.05)。治疗后增殖期子宫内膜32例(26.67%),分泌期子宫内膜76例(63.33%),增殖期子宫内膜伴局灶单纯型增生12例(10.00%)。结论3个月的炔诺酮可有效治疗子宫内膜单纯型增生。
Objective To study the change of hormone level,clinic symptom and endometrium in endometrial hyperplasia patients after three periods treatment by Norethindrone.Methods A single-blind randomized controlled clinical trial was conducted. 120 cases of endometrial hyperplasia （EH） diagnosed by pathological examination were treated with Norethindrone from the 5th day to 25th day after curettage and the next two menstrual cycles. Menstrual duration,amount of flow,interval between periods were observed. The pathology of endometrium and hormone level were detected after the third menstruation.Results There was no significant difference in hormone level before and after Norethindrone treatment（P0.05）. After three periods treatment by Norethindrone,the menstrual duration shortened obviously from （21.37±0.56） days to （6.43±0.90） days,the amount of flow and clots decreased. After treatment,32 cases （26.67%） of proliferative endometrium,76 cases （63.33%） of secretory endometrium and 12 cases （10.00%） of proliferative endometrium with local simple hyperplasia were detected by curettage followed eith pathological diagnosis.Conclusion Three months treatment of Norethindrone is an effective method for endometrial simple hyperplasia.
出处
《中国妇产科临床杂志》
2010年第1期18-20,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
关键词
功能失调性子宫出血
子宫内膜增生
炔诺酮
dysfunctional uterine bleeding
endometrial hyperplasia
norethindrone.
