摘要
目的分析妊娠24～28周孕妇外周血C-反应蛋白(CRP)水平、体重指数(BMI)与妊娠期糖尿病(GDM)的相关性,为寻找早期预测GDM的生物学指标提供前期研究。方法妊娠24～28周GDM孕妇35例(GDM组)及同期糖耐量正常(NGT)孕妇30例(NGT组)均采用免疫透射比浊法检测孕妇外周血CRP表达水平。结果GDM组与NGT组CRP水平比较,差异无统计学意义(t=1.67,P>0.05);GDM组孕中期BMI较NGT组高,差异有统计学意义(t=2.27,P<0.05);孕前BMI与血清CRP成正相关(r=0.63,P<0.01);GDM组孕前肥胖比例较NGT组高,差异有统计学意义(χ2=7.47,P<0.01)。结论CRP对GDM的独立影响不能被证实,而GDM患者血清CRP水平与孕前BMI有正相关关系,GDM组孕前肥胖比例高,孕前肥胖是GDM的独立高危因素。
Objective To evaluate the role of C-reactive protein （CRP） and body mass index （ BMI） in the pathogenesis of gestational diabetes mellitus （GDM）. Methods The levels of CRP were determined using particle enhanced immunoturbidimetic assay among 35 pregnant women with GDM （ GDM group） and 30 normal pregnant women （control group） in their gestational weeks of 24 to 28. Results There was no statistical significance in the level of CRP between GDM group and control group （ t = 1.67, P 〉 0. 05 ）. Mean BMI of GDM group was significant higher than that of control group （ t = 2.27, P 〈 0. 05 ）. A positive correlation was noted between level of CRP in second trimesters and preconception BMI in all women （ r = 0. 63, P 〈 0. 01 ）. There were more obese women during preconception period in GDM group compared with control group （X^2 = 7. 47, P 〈 0.01 ）. Conclusion CRP level is positively correlated with BMI in the second trimester. Inflammatory reaction mediated by obesity may induce insulin resistance and glycometabolism disorder, although it can＇t confirm that systemic inflammation is an risk factor for GDM. It is supposed that the association of CRP and GDM is dependent of maternal pregnancy adiposity. Pre-pregnancy adiposity is a risk factors for GDM.
出处
《中国生育健康杂志》
2009年第6期338-340,共3页
Chinese Journal of Reproductive Health
关键词
妊娠期糖尿病
C反应蛋白
体重指数
Gestational diabetes mellitus
C-reactive protein
Body mass index
