摘要
目的探讨基质金属蛋白酶-2(matrix metalloproteinases,MMP-2)及基质金属蛋白酶-9(matrix metalloproteinases,MMP-9)与乳头状甲状腺癌的关系。方法采用酶联免疫吸附法测定30例健康者(对照组)和30例甲状腺腺瘤患者及32例乳头状甲状腺癌患者血清中MMP-2和MMP-9的水平,分析其与乳头状甲状腺癌之间的关系。结果乳头状甲状腺癌组血清中MMP-2和MMP-9的水平显著高于甲状腺腺瘤组和健康对照组(P<0.01)。甲状腺腺瘤组和健康对照组之间没有差异(P>0.05)。结论血清中MMP-2和MMP-9水平的检测对乳头状甲状腺癌患者的诊断有重要的临床意义。
Objective To investigate the significance of matrix metalloproteinase - 9 （ MMP - 9） and matrix metalloproteinase - 2 （ MMP - 2 ） expression in human papillary thyroid carcinomas. Methods Expression of MMP - 9 and MMP- 2 in serum of 32 patients with papillary thyroid carcinoma 30 patients with thyroid adenoma and 30 healthy control ones were detected by ELISA respectively. Results The expression of MMP -9 and MMP -2 in patients with papillary thyroid carcinoma was significantly higher than that of thyroid adenoma and healthy control （ P 〈 0.01 ）, while there was no significant difference between patients with thyroid adenoma and healthy control in the expression of MMP -9 and MMP -2. Conclusion The overexpression of MMP -9 and MMP -2 is significantly
出处
《青海医学院学报》
CAS
2009年第4期258-260,共3页
Journal of Qinghai Medical College
