摘要
目的:对广东省实施的地中海贫血(地贫)综合干预措施进行效果评价,为进一步干预措施的制定提供参考依据。方法:利用2005～2008年广东省出生缺陷医院监测网报告的胎儿水肿综合征和地中海贫血病例进行回顾性的趋势分析和因素分析。结果:2005～2008年广东省胎儿水肿综合征的发生率呈下降趋势,分别为24.3/万、21.7/万、17.2/万、21.7/万,地贫发现率2006～2008年分别为7.3/万、2.7/万、4.0/万,呈下降趋势;这两个率的下降主要是因为孕28周前因产前诊断或其它原因而终止妊娠导致的,城乡间的产前诊断水平和服务差异有统计学意义;胎儿水肿综合征的地贫确诊检测比例较低。结论:广东省地中海贫血综合干预取得了一定的效果,主要是由于早期产前诊断的水平提高所致;对于胎儿水肿综合征的地贫确诊检测有待加强。
Objective： To evaluate the effect of integrated intervention on thalassemia in Guangdong, provide reference evidence for further intervention. Methods： Retrospective trend analysis and related factors analysis were applied on reported cases with schridde syn- drome and thalassemia from birth defect surveillance net based on hospital in Guangdong from 2005 to 2008. Results： The incidences of schridde syndrome in Guangdong from 2005 to 2008 were 24. 3/10 000, 21.7/10 000, 17. 2/10 000 and 21.7/10 000, respectively, showing a trend of decline; the incidences of thalassemia in Guangdong from 20065 to 2008 were 7.3/10 000, 2.7/10 000 and 4. 0/10 000, respectively, showing a trend of decline. The main effect factor of decline of incidenees of schridde syndrome and thalassemia was termination of pregnancy before 28 gestational weeks because of prenatal diagnosis and other causes, and there was significant difference in prenatal diagnosis level and services between urban areas and rural areas. The final diagnostic rate of thalassemia was low in eases with schridde syndrome. Conclusion： The integrated intervention on thalassemia in Guangdong is effective, resulting from increase of prenatal diagnosis level; the final diagnosis of thalassemia for cases with schridde syndrome should be strengthen.
出处
《中国妇幼保健》
CAS
北大核心
2010年第3期297-299,共3页
Maternal and Child Health Care of China
基金
广东省科技厅资助项目(2005B34201015)
关键词
地中海贫血
胎儿水肿综合征
效果评价
干预
Thalassemia
Schridde syndrome
Effectiveness evaluation
Intervention
