摘要
目的：对影响CsA血药浓度的因素进行初步探讨。方法：采用FPIA法测定132例肾移植受者的CsA血药浓度，观察肝功能等对CsA血药浓度的影响。结果：肝功能异常，合并应用酮康唑、氟康唑、地尔硫、异烟肼及雷尼替丁等药物均可使CsA血药浓度显著升高，腹泻、喝浓茶等可使CsA血药浓度显著降低。此外，在术后早期部分患者CsA血药浓度与血RBC及HGB含量有显著正相关。结论：监测CsA血药浓度必须结合患者的实际情况具体分析，及时调整用药方案。
OBJECTIVE:To study some factors that affect the blood concentration of cyclosporine A (CsA).METHODS:The bloodconcentrations of CsA were detected with FPIA method in 132 renal transplanted recipients.The liver function and so on that mightaffect the blood concentration of CsA were observed. RESULTS: The concentration of CsA increased in the patients with abnormalliver functions and in combined-use with ketoconazole , nuconazole , diltiazem, isoniazid and ranitidine, decrsased significantly inpatients complicated diarrhea or after drinking strong tea.Besides above-mentioned factors,the blood concentration of CsA waspositively related with the count of red blood cells and the hemoglobin of the recipinets during early postoperativeperiod. CONCLUSION:In evaluating the blood concentration of CsA, we must link it with the actnal situatin of recipients toregulate the dosage of CsA on time.
出处
《中国药房》
CAS
CSCD
1998年第6期272-273,共2页
China Pharmacy
关键词
环孢素A
血药浓度
药理
cyclosporine A blood concentration of drug affecting factor
