摘要
目的：探讨ＮＯ与牙髓炎性痛过敏的关系。方法：应用组织化学方法，研究了牙髓炎症不同阶段三叉神经节和三叉神经脊束核尾侧亚核ＮＯ合酶（ｎｉｔｒｉｃｏｘｉｄｅｓｙｎｔｈａｓｅ，ＮＯＳ）阳性神经元的变化。结果：在与传递伤害性信息有关的三叉神经节中、小型细胞和三叉神经脊束核尾侧亚核的Ⅰ、Ⅱ层均有ＮＯＳ阳性神经元的出现；三叉神经节在牙髓炎症１４ｄ组、２１ｄ组，三叉神经脊束核尾侧亚核在炎症１４ｄ组阳性神经元均有明显增多。
Aim: To explore the relationship between NO and intradental inflammatory hyperalgesia. Methods: Histochemical methods had been used to study the change of NOS (nitric oxide synthase, NOS) in trigeminal ganglion and trigeminal spinal caudal subnucleus during pulpitis. Results: NOS was found in small to medium neurons of trigeminal ganglion and Ⅰ-Ⅱ laminae neurons of trigeminal spinal caudal subnucleus, which were believed relating to the transmission of noxious stimulation; the number of NOS positive neurons increased, either in trigeminal ganglinal ganglion at 14d and 21d respectively, or in trigeminal spinal caudal subnucleus at 14d. Conclutions: The results suggested that NO might take part in the peripheral and central regulation of chronic intradental hyperalgesia.
出处
《牙体牙髓牙周病学杂志》
CAS
1998年第3期165-167,共3页
Chinese Journal of Conservative Dentistry
基金
国家自然科学基金
关键词
牙髓炎
一氧化氮合酶
三叉神经节
病理
pulpitis NOS trigeminal ganglion trigeminal spinal caudal subnucleus
