摘要
目的回顾性分析鼻咽癌治疗临床效果,探讨进一步提高鼻咽癌治疗疗效的途径。方法对2005—2008年在我科接受根治性放射治疗的208例鼻咽癌患者进行随访,所有患者均接受6MV-X线、9～12MeV电子线照射,剂量范围64～80Gy。其中149例患者配合化疗,化疗方案均采用5-FU+DDP,化疗周期2～6周期。结果全组患者1年、3年总生存率(OS)及无病生存率(DFS)分别为90.8%、87.7%和79.3%、62.1%。Ⅲ、Ⅳ期患者中同步放化疗组的2年生存率为87.2%,明显高于单纯根治性放疗组的76.9%(P<0.05)。急性口腔黏膜炎发生率为61.2%,骨髓抑制发生率为31%。结论鼻咽癌放射治疗的疗效确切,临床分期是影响预后的主要因素,同步放化疗能明显提高晚期鼻咽癌患者的2年生存率。
Objective To analyze the results of nasopharyngeal carcinoma treated by radical radioherapy, and explore the prognostic factors of patients. Methods Two hundred and eight patients with nasopharyngeal carcinoma who were treated in our department were analyzed retrospectively. All patientswere irradiated with 6-MV photons and the total dose rang was 64-80 Gy. 149 patients received additiona chemotherapy. Results The 1-year and 3-year overall survival rates and disease free survival were 90. 8%, 87.7% and 79. 3%, 62. 1%, 62. 1%, respectively. The 2-year survival rates of advanced stage patients with radical radiotherapy alone and the concurrent chemoradiotherapy group were 76. 9% and 87.2%, respectively （P 〈0. 05 ） The incidence of acute oral mueositis was 61.2%, bone marrow suppression rate was 31%. Conclusion The treatment resuits of nasopharyngeal carcinoma were confirmed, clinical stage was the most important prognostic factors, the concurrent chemoradiotherapy can significantly improve the 2-year survival rate of advanced stage patients with nasopharyngeal carcinoma.
出处
《广州医药》
2010年第1期19-21,共3页
Guangzhou Medical Journal
关键词
鼻咽癌
放射治疗
疗效分析
Nasopharyngeal carcinoma
Radiotherapy
Treatment analysis
