摘要
目的探讨达因35联合来曲唑对有生育要求的多囊卵巢综合征(PCOS)患者促排卵治疗的效果。方法将59例有生育要求的PCOS患者分为2组,无胰岛素抵抗患者30例(A组),有胰岛素抵抗患者29例(B组)。先行基础治疗:A组自月经周期第5天起口服达因351片/d,3个月1个疗程,第2个疗程为1个月;B组连服用达因35方案同A组,加服二甲双胍0.5g/次,3次/d。促排卵治疗:2组在月经周期第5天起服用来曲唑2.5mg,连用5d,逐月增加2.5mg/d不超过3个周期,直至卵泡直径>19mm,对不能排卵患者用HCG5000～10000U肌注促其排卵。对2组基础治疗效果及排卵率进行比较。结果2组基础治疗均有效,黄体生成素(LH)、LH/FSH及睾酮(T)与治疗前比较,差异均有统计学意义(均P<0.05);2组排卵率分别是93.3%和89.6%,差异无统计学意义(P>0.05)。结论来曲唑联合达因35治疗对有生育要求的PCOS患者的促排卵治疗有良好的效果。
Objective To evaluate the effect on infertile patients of polycystic ovarian syndrome（PCOS） treated to stimulated ovulation by Letrozole and Diane 35.Methods 59 infertility patients with PCOS were divided into 30 cases of A group and 29 cases of B group,A group was PCOS only,B group was PCOS and insulin resistance（IR）.Basic treatment first：A groups received Diane 35 1p/d for three months during days 5 of menstrual circle,then for one month;B groups received the same,and added metformin 0.5 g/d（divided 3 times）.then treated to induced ovulation：two groups all received letrozole 2.5 g/d for five days during days 5 of menstrual circle,added 2.5 g/d every month until the third month or the diameter of the biggest follicle reached 19 mm.if can not ovulate,5000～10 000 U HCG was injected to trigger ovuliaion.To contrast the effectand ovulation rate between two groups.Results The basic treatment of two groups all can attain good effect,LH,LH/FSH and T all have statistical difference（P〈0.05 ）after treatment.The ovulation rate of A group was 93.3% and B group was 89.6%,this result has no significant（〈0.05 ）.Conclusions The infertile patients of PCOS were treated to good results with Letrozole and Diane 35.
出处
《江西医学院学报》
2009年第9期64-66,69,共4页
Acta Academiae Medicinae Jiangxi
