摘要
１０４例晚期癌痛病人，Ｌ２～３或Ｌ３～４硬膜外间隙置管并连接全封闭硬膜外注射（ＣＣＥＩ）装置，注射０．０１％吗啡１０～１５ｍｌ，２～３次ｄ，去炎松Ａ４０ｍｇｄ，应用ＣＣＥＩ５０．０±４６．８（５～３５１）天未发现硬膜外腔感染，日均注射吗啡３．８４±３．９４ｍｇ和２．９９±１．１７次，不良反应率为７．６９％，ＣＣＥＩ吗啡初始量３．５５±２．５２ｍｇｄ，对照死亡前量３．４９±１．６３ｍｇｄ无显著差异（Ｐ＞０．０５）。死亡前平均视觉模拟评分３．１６±２．８３分，对照治疗前９．７８±０．９２分差异显著（Ｐ＜０．０５）。吗啡去炎松长期ＣＣＥＩ具有良好解除疼痛和防止硬膜外腔感染功能，同时也减少病人吗啡用量和不良反应。
patients with advanced cancer pain who had been treated with traditional opiates, but the effects were not satisfactory. They were inserted with epidural cathter at L 2～3 or L 3～4 and connceted with a Complete Close Epidural Injection (CCEI) device. 0.01% Morphine (M) 10～15ml bid or tid and Triamcinelone A(TA) 10mg per week. There were no epidural infection during 5～351 days (50.0±46.8, x ±S). The mean dosage of M was 3.84±3.98mg/d and the mean frequancy of injection was 2.99 times/d through CCEI device. The side effect rate was 7.69%. The initial dosage of M (3.55±2.52mg/d) was not different from that (3.49±1.63mg/d) one week before death (P>0.05). But there were statistic difference between mean VAS 9.78±0.92 before treatment and VAS 3.16±2.82 after treatment (P<0.05). A long term application of M TA by CCEI can effectively relieve pain and avoid epidural infection, and also reduce the M dosage and its side effects.
出处
《中国疼痛医学杂志》
CAS
CSCD
1998年第3期129-134,共6页
Chinese Journal of Pain Medicine
关键词
晚期癌痛
癌痛
吗啡
去炎松A
硬膜外注射
Cancer pain
Complete close epidural injection
Morphine
Triamcinolone A
