摘要
目的探索建立强迫症的睡眠图模式。方法对３０例强迫性神经症患者的多导睡眠图和血小板５羟色胺（５ＨＴ）含量进行测试，并与３０名正常受试者进行对照。结果强迫症组多导睡眠图改变主要有快眼动（ＲＥＭ）睡眠潜伏期缩短，ＲＥＭ活动度、ＲＥＭ强度和ＲＥＭ密度增高，以及第１次ＲＥＭ睡眠时间（ＦＲＴ）及其百分比（ＦＲＴ％）增高等；强迫症组血小板５ＨＴ含量明显高于对照组，并与ＦＲＴ、ＦＲＴ％呈正相关。结论ＲＥＭ睡眠指标的改变可能代表了强迫症患者的某些生物学特征。
Objective The goal of this study was to establish the polysomnographic model of obsessivecompulsive disorder (OCD).Methods The polysomnograms and platelet 5HT level were examined in 30 OCD patients and 30 normal controls.Results Compared with the normal control, shortened REM sleep latency (RL), increased REM activity (RA), REM intensity (RI) and REM density (RD) were found in patients. Platelet 5HT level was significantly elevated in patients and there was a significantly positive correlation between platelet 5HT level and first REM sleep time (FRT) or FRT%.Conclusion The findings indicate that the changes of REM sleep variables might be the biological markers of patients with OCD.
出处
《中华精神科杂志》
CAS
CSCD
1998年第3期163-165,共3页
Chinese Journal of Psychiatry
