摘要
目的检测食管鳞癌组织中VEGF165b和HIF-1α的表达及与临床病理特征的关系。方法应用免疫组织化学SP法检测143例食管鳞状细胞癌组织中VEGF165b和HIF-1α的表达。结果VEGF165b和HIF-1α在食管鳞癌组织中的阳性表达率分别为13.3%和43.4%;VEGF165b阳性表达率与HIF-1α阳性表达率呈负相关关系(P=0.035)。HIF-1α阳性表达率与饮酒程度、分期、纵隔淋巴结转移及肿瘤的分化程度呈正相关(P<0.05)。结论VEGF165b和HIF-1α在食管癌的发生发展和淋巴转移中起重要的作用,VEGF165b的表达与HIF-1α存在相关性,饮酒是食管癌的重要危险因素。VEGF165b可能成为治疗的靶点。
Objective To detect the expression of VEGF165band HIF-1α in esophageal squamous carcinoma tissues and their significance. Methods Immunohistochemistry SP method was used to detect the expression of VEGF165b and HIF-1α in 143 cases of esophageal squamous carcinoma tissues. Results The positive expression rate of VEGF165b and HIF-1α in esophageal squamous carcinoma tissues was 13. 3% and 43. 4% respectively; The expression rate of VEGF165b showed a negative correlationwith that of HIF-la （P = 0. 035）. Alcohol drinking was positively correlated with the expression rate of HIF-1α （P = 0. 027）. The expression rate of HIF-1α showed a positive correlation with the depth of invasion, lymph node metastasis and pathologic grades. Conclusion The expression of VEGF165b and HIF-1α played an important role in the development of esophageal squamous carcinoma, and the VEGF165b, and HIF-1α may have a synergistic effect in the pathogenesis of esophageal carcinoma. Alcohol drinking was an important risk factor of esophageal carcinoma and VEGF165b may be a potential therapy target.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2010年第1期9-11,共3页
Cancer Research on Prevention and Treatment
