摘要
目的:比较黄连中主要生物碱成分在黄连-吴茱萸药对配伍前后的差异。方法:采用TLCS法对黄连单煎液、黄连吴茱萸合煎液、黄连吴茱萸单煎混合液中盐酸小檗碱、盐酸巴马汀、盐酸药根碱的含量进行测定。结果:黄连与吴茱萸配伍后,盐酸小檗碱、盐酸巴马汀、盐酸药根碱的含量均显著降低,以盐酸小檗碱的减少较为明显。结论:两药合用,黄连生物碱含量均有不同程度降低,说明吴茱萸可制约黄连苦寒之性,为临床两药配伍使用提供了实验依据。
AIM ： To investigate the changes of alkaloid in Rhizoma Coptidis and Fructus Evodiae before and after combination. METHODS： The content of berberine hydrochloride, palmatine hydrochloride, jatrorrhizine hydrochloride in Rhizoma Coptidis and Fructus Evodiae before and after combination were determined by TLCS. RESULTS： After combination of Rhizoma Coptidis and Fructus Evodiae, contents of berberine hydrochloride, palmatine hydrochloride, jatrorrhizine hydrochloride significantly reduced, among which the reduction of berberine hydrochloride was more obvious. CONCLUSION： In decoction, Fructus Evodiae appears to restrict the alkaloid from Rhizoma Coptidis in order to lower the side effect of Rhizoma Coptidis.
出处
《中成药》
CAS
CSCD
北大核心
2010年第1期75-79,共5页
Chinese Traditional Patent Medicine
基金
国家自然科学基金资助项目(30873369)
关键词
黄连
吴茱萸
薄层扫描法
盐酸小檗碱
盐酸巴马汀
盐酸药根碱
Rhizoma Coptidis
Fructus Evodiae
TLCS
berberine hydrochloride
palmatine hydrochloride
ja- trorrhizine hydrochloride
