摘要
目的:研究三种促透皮吸收剂即脂溶性氮酮、水溶性氮酮、二甲基亚砜对脂溶性基质脐中穴经皮给药制剂吸收的促透作用。方法:制备含不同浓度的促透皮吸收剂的脂溶性基质的制剂,将昆明小鼠脐部皮肤剥离,进行预处理,采用Franz扩散池体外透皮试验,于不同时间取样,用高效液相色谱法测定接收池中制剂主要成分的含量。结果:加入促透皮吸收剂的最适宜水平组与空白组透过量有显著性差异,P<0.05;脂溶性氮酮组、水溶性氮酮组1%～5%、二甲基亚砜用量在30%～35%均有较好的促透作用,其中脂溶性氮酮组2%为最优,经皮吸收量与时间呈正相关性;与氮酮浓度无相关性;脂溶性氮酮组高于相应水溶性氮酮组。结论:加入促透皮吸收剂的最适宜水平组与空白组透过量有显著性差异(P<0.05);经皮吸收量与时间呈正相关性;脂溶性氮酮组高于相应水溶性氮酮组。
Objective： Studies three kinds to press thoroughly the skin absorbent is the fat soluble nitrogen alkone, the water- soluble nitrogen alkone, the dimethylsulfoxide the hole the preparation absorption presses thoroughly the function to the fat soluble matrix navel in giving medicine by skin. Methods： The preparation pressed thoroughly the skin absorbent including the different density the fat soluble matrix preparation, the Kunming mouse navel region skin peeling, would carry on the pretreatment, used outside the Franz proliferation cell body to pass the skin experiment, in the different time sample, determined in the receive pond with the highly effective liquid phase chromatography the preparation principal constituent content. Results： Pressed thoroughly the medicinal preparation fat soluble nitrogen alkone group, the water- soluble nitrogen alkone group 1% -5 % , dimethylsulfoxide amount used in 30 - 35% to have well presses thoroughly the function, fat soluble nitrogen alkone group 2% for most superior. Conclusions： Joins pressed thoroughly the skin absorbent to be suitable the horizontal group and the blank group had the significant difference by the quantity; After skin absorbing capacity and time present relevance; The fat soluble nitrogen alkone group is higher than the corresponding water- soluble nitrogen alkone group.
出处
《中医药信息》
2010年第1期20-22,共3页
Information on Traditional Chinese Medicine
基金
国家"十一五"科技支撑计划项目(2006BAI09B08-10)
关键词
促透剂
脂溶性基质制剂
脐中穴经皮给药
Presses thoroughly the medicinal preparation
Fat soluble matrix preparation
Give medicine after skin in navel hole
