摘要
目的探讨癫痫患者新发作类型出现的比例及可能原因，为正确诊断、治疗和预防癫痫提供依据。方法回顾性研究1074例癫痫患者的临床资料，分析癫痫患者新发作类型的发生率、可能原因、脑电图和神经影像学结果、家族史及神经系统检查。采用独立样本秩和检验比较有或无新发作类型出现的癫痫患者的发病年龄及病程差异。χ^2检验比较有或无新发作类型出现的癫痫患者的性别、家族史、神经系统检查以及脑电图和神经影像学出现异常比例的差异。结果1074例患者中231例（21．5％）出现新的发作类型，其中部分性发作患者584例，132例（22．6％）出现新的发作类型；全面性发作患者490例，99例（20．2％）出现新的发作类型。1074例癫痫患者中脑电图异常者576例（53．6％），影像学异常237例（22．1％）。231例出现新发作类型的癫痫患者中123例（53．2％）出现脑电图异常，75例（32．5％）影像学异常。有41例患者可找到出现新发作类型的可能原因。有和无新发作类型的癫痫患者的首次发病年龄差异无统计学意义，平均病程（Z=2．024）、神经系统体格检查和影像学检查结果有异常的比例（χ^2=23．836、18．511）差异均有统计学意义（P〈0．05）。结论一部分出现新发作类型的患者可找到原因，分析新发作类型的出现、原因对癫痫的诊断、治疗和预防有指导意义。
Objective To study the percentage and cause of new seizure types in epilepsy patients and attempt to evaluate the value of new seizure types. Methods All 1074 eapilepsy patients were enrolled in the retrospectively study. The types of seizure were diagnosed according to International League Against Epilepsy seizure classification and neuroimaging results of the patients. The Wilcoxon signed rank sum test was used to assess the difference of age at first seizure and mean duration of epilepsy patients with and without new seizure types. The ehi-square test was used to compare the abnormal proportion of EEG and neuroimaging results of epilepsy patients. Results Two hundred and thirty-one （21.5%） of 1074 epilepsy patients experienced new seizure type. Five hundred and eighty-four patients had partial seizure with 132 （22. 6% ） experiencing new types of seizure while 490 patients had generalized seizure with 99 （20. 2% ） experiencing new types of seizure. Five hundred and seventy-six （53.6%） had abnormal EEG and 237 （22. 1% ） had abnormal neuroimaging in 1074 epilepsy patients. A hundred and twenty-three （52. 3% ） of 231 patients with new seizure types had abnormal EEG, and 75 （32.5%） of them had abnormal neuroimaging. The possible causes for the new types of seizure could be found in 41 patients. There were no significant difference in the age of the first onset between the patients with and without the new types of seizure while there was significant difference in the average course of disease between them （χ^2 = 18. 511- 23. 836, P 〈 0. 05）. There were significant differences in the rates of abnormal results of examination of nervous system and imaging outcomes. Conclusions There may be different causes of new seizure types. The study of new seizure types is helpful in diagnosis, treatment and prevention of epilepsy.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2010年第1期31-34,共4页
Chinese Journal of Neurology
关键词
癫痫
发作
脑电描记术
Epilepsy
Seizures
Electroencephalography
