摘要
目的:观察由泮托拉唑、替硝唑、阿莫西林、克拉霉素组成的10日序贯疗法根除幽门螺杆菌(H pylori)的疗效.方法:将经胃镜检查确诊为慢性胃炎和消化性溃疡且H pylori阳性的患者120例随机分为两组,治疗组(62例)方案为前5d给予泮托拉唑+阿莫西林,后5d给予泮托拉唑+克拉霉素+替硝唑;对照组(58例)三联疗法为泮托拉唑+阿莫西林+克拉霉素,疗程7d.比较治疗后两组患者H pylori根除率.结果:治疗组和对照组H pylori ITT根除率分别为83.87%和67.24%,PP根除率分别为89.66%和72.22%,两组分别有统计学意义(P<0.05).结论:含替硝唑的10日序贯疗法治疗H pylori感染具有较高的根除率.
AIM： To compare the efficacy of tinidazolecontaining sequential therapy versus the standard triple therapy in the eradication of Helicobacter pylori （H pylori） infection. METHODS： A total of 120 H pylori-infected patients with endoscopicaUy diagnosed peptic ulcer or chronic gastritis were enrolled. The patients were randomly divided into trial group （n = 62） and control group （n = 58）. The trial group received pantoprazole 40 mg plus amoxicillin 1.0 g for 5 days, and pantoprazole 40 mg plus clarithromycin 500 mg and tinidazole 500 mg for another 5 days, while the control group received the standard 7-day triple therapy （pantoprazole 40 mg plus clarithromycin 500 mg and amoxicillin 1 g for 7 days）. All drugs were given twice daily. H pylori infection status was compared between the two groups after completion of treatment. RESULTS： The eradication rates achieved in the trial group were significantly greater than those in the control group in the intention-to-treat analysis （83.87% vs 67.24%, P 〈 0.05） and the perprotocol analysis （89.66% vs 72.22%, P 〈 0.05）. CONCLUSION： The 10-day tinidazole-containing sequential therapy can achieve a higher eradication rate of H pylori infection than the standard 7-day triple therapy.
出处
《世界华人消化杂志》
CAS
北大核心
2009年第35期3666-3669,共4页
World Chinese Journal of Digestology
关键词
替硝唑
幽门螺杆菌
序贯疗法
Tinidazole
Helicobacter pylori
Sequential therapy
