摘要
比较三种定量测定AFP方法的性能及其性价比和评价临床意义。采用ELISA、R IA和化学发光酶免疫（CLEIA）法,分别检测326例肝病患者和100名健康体查者（对照组）血清AFP水平。结果表明,三种方法皆能反映血清AFP水平（P〉0.05）,具有良好的重复性和敏感性,两两比较的相关系数为0.96~0.99,呈高度相关;原发性肝癌组血清AFP阳性率最高,高水平升高所占比例也显著高于肝炎组和肝硬化组。这三种方法各有优缺点,但均符合临床诊断要求,各级医疗单位可以根据自己的财力选择。AFP对原发性肝癌具有重要的诊断意义,是发现早期肝癌的主要指标之一。
To compare three methods of AFP determination and its cost-effective performance, the serum AFP levels in 326 patients with liver diseases and 100 normal controls were determined by ELISA, RIA and chemilu-minescenoimmunoassay（CLEIA） method. The results showed that three methods accurately reflected serum AFP levels （P 〉0.05）. They all had good reproducibility and sensitivity, and the correlation coefficient between methods was from 0.96 to 0.99. The positive rate of high level of serum AFP in primary hepatic carcinoma group was significantly higher than that of other two groups. The three methods had their own feature but they all met the clinical diagnosis requirements. The detection of AFP had an important role and might be regarded as an index in the diagnosis of primary hepatoma in early stage.
出处
《标记免疫分析与临床》
CAS
2009年第6期380-383,共4页
Labeled Immunoassays and Clinical Medicine
关键词
甲胎蛋白定量
质量评价
方法
原发性肝癌
Quantitative determination of AFP
Quality evaluate
Method
Primary hepatic carcinoma
