摘要
目的探讨性激素变化与肝硬化发生的关系。方法采用放射免疫法检测80例肝硬化患者和20例健康男性(对照组)的血清性激素水平,并采用Child-pugh分级法将上述病例分为A级组、B级组和C级组进行比较。结果各肝硬化组T、E2的平均水平均降低于正常对照组(P<0.01),FSH、LH、PRL高于正常对照组(P<0.01);Child分级与T、E2含量呈负相关(r=-0.55,r=-0.49,P<0.05);与PRL、LH、FSH含量呈正相关(r=0.43,r=0.47,r=0.46,P<0.05)。结论肝硬化存在不同程度的性激素紊乱,测定性激素水平变化,可以作为临床判断预后、疗效的一个指标。
Objective To investigate the relationship between the Changes in serum sex hormone level and liver cirrhosis. Methods The serum sex hormone level was measured by radioimmunoassay in 80 cases of liver cirrhosis and 20 normal subjects. The 80 cases of hver cirrhosis were divided into A-,B- and C-level groups based on Child-pugh classification and the comparison was made between the groups. Results The levels of T and E2 in the liver cirrhosis groups（A-,B- and C-level groups）were lower than the normal control group（P〈0.01） and the levels of FSH,LH and PRL were higher than the normal control group（P〈0.01 ）. The Child-pugh classification was negatively correlated with T and E2 levels（r=- 0.55, r=-0.49, P〈0.05 ） and was positively correlated with the PRL, LH and FSH levels（r=0.43 ,r=0.47, r= 0.46, P〈0.05）. Conclusion There are different levels of sex hormone disorder in liver cirrhosis, and the determination of changes in the sex hormone level can be used as an indicator of the clinical prognosis
出处
《中国现代医生》
2010年第1期5-6,共2页
China Modern Doctor
关键词
肝硬化
性激素
睾酮
雌二醇
催乳素
Liver cirrhosis
Sex hormone/testosterone
Estradiol
Prolactin
