摘要
高血压是心血管疾病最重要的且可治疗的危险因素之一,控制高血压是降低心脑血管疾病的发病率、致残率和死亡率的有效措施。血管紧张素转化酶通过影响肾素-血管紧张素系统和激肽释放酶-激肽系统实现对人体血压调节。文章综述了血管紧张素转化酶抑制肽的总体研究趋势、物理化学及酶稳定性的研究现状,并对其值得进一步研究内容进行展望,旨在为血管紧张素转化酶抑制肽的研究与开发提供思路。
High blood pressure is one of the main and remediable risk factor for cardiovascular disease.Angiotensin I converting enzyme（ACE, EC 3.4.15.1 ）is also known as peptidyl dipeptidase A. One of its key actions is the regulation of blood pressure, since it cleaves angiotensin I into the potent vasopressor angiotensin Ⅱ. It also inactivates brady kinin,which is a hypotensive peptide, by sequential removal of two C-terminal dipeptides.So,the result of ACE action is an elevation of blood pressure.The paper reviewed the overall investigation and stability process of the angiotensin converting enzyme inhibitory peptides.
出处
《食品工业科技》
CAS
CSCD
北大核心
2010年第1期412-414,共3页
Science and Technology of Food Industry
基金
国家高技术研究发展计划(863)项目(2007AA10Z329)
关键词
血管紧张素转化酶抑制肽
稳定性
降血压
综述
angiotensin converting enzyme inhibitory peptides
stability
antihypertensive
review
