摘要
目的：观察氟比洛芬酯联合芬太尼用于腹腔镜手术术后镇痛的效果和不良反应。方法：选择腹腔镜手术患者54例，ASAⅠ～Ⅱ级，随机分为两组。镇痛组（26例）术后联合应用氟比洛芬酯和芬太尼行静脉自控镇痛（PCIA）。镇痛泵内药物组成：芬太尼0．5mg、氟比洛芬酯100mg、恩丹西酮8mg用生理氯化钠溶液稀释至80mL，背景输注2mL·h^-1，患者自控镇痛（PCA）0．5mL，锁定时间15min。对照组（28例）术后不使用镇痛装置。评估术后4，8，24，48h的疼痛程度，记录不良反应及手术当晚的睡眠情况。结果：镇痛组疼痛评分（VAS）显著低于对照组，睡眠情况优于对照组，两组不良反应无显著差异。结论：氟比洛芬酯联合芬太尼用于腹腔镜手术术后静脉自控镇痛效果确切，是腹腔镜手术术后镇痛的良好选择。
Objective：To evaluate the efficacy of flurbiprofen axetil combined with fentanyl for postoperative analgesia in patients undergoing laparoscopic surgery. Methods：Patients （ASAⅠ-Ⅱ ） undergoing laparoscopic surgery （ n = 54） were randomly divided into control （ n = 28） and analgesia （ n = 26） groups. The analgesia group received patient-controlled intravenous analgesia （PCIA） with flurbiprofen axetil and fentanyl,namely flurbiprofen axetil 100 mg ＋ fentanyl 0.5 mg ＋ ondansetron 8mg that was diluted with 80 mL saline. PCIA was performed as following：a bolus of 0.5 mL, lockout time of 15 min,and background dose of 2 mL·h^-1. Postoperative pain was assessed by visual analogue scale （VAS） at 4,8,24 and 48 h after the surgery. Side effects and sleep quality were also recorded. Results：The VAS was significantly lower in analgesia group than in control group. Sleep quality was better in the analgesia group. There was no difference of side effects in the two groups. Conclusion：Co-administration of flurbiprofen axetil and fentanyl by PCIA is an effective method for postoperative analgesia in patients undergoing laparoscopic surgery.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2010年第1期42-44,共3页
Chinese Journal of New Drugs
关键词
氟比洛芬酯
芬太尼
术后镇痛
腹腔镜
手术
flurbiprofen axetil
fentanyl
postoperative analgesia
laparoscope
surgery
