摘要
目的探讨预缺血对长时间缺血／再灌注心肌的保护作用。方法在氨基甲酸乙酯麻醉家兔心肌模型上，观察缺血／再灌注组和预缺血组对血流动力学、心功能、心肌耗氧量、心外膜电图和心肌梗塞范围的影响，并对结果进行统计分析。结果两组在缺血／再灌注过程中，血流动力学，心功能，心肌耗氧量均明显持续性降低，且两组间心肌耗氧量存在明显差异；心外膜电图ＳＴ段在缺血过程中明显抬高；缺血／再灌注组和预缺血组的心肌梗塞范围分别为３２．３％和２１．６％，有明显差异（Ｐ＜０．０１）。结论预缺血可降低心肌耗氧率，减轻心肌损伤。
Objective To research the protection on myocardium with more prolonged ischemia-reperfusion provided by ischemic preconditioning in urethane-anesthetizied rabbits.Methods The effects of ischemia-reperfusion group and ischemic preconditioning group on the hemodynamics, cardic function, myocardial oxygen consumption ,epicardial electrographic,infarct size were examined in urethane-anesthetized rabbit models.the results were analysized by statistic method.Results In the course of ischemia(30min)/reperfusion(180min),all hemodynamic parameters,cardiac function and myocardial oxygen consumption were decreased progressively significantly, while myocardial oxygen consumption in the both groups showed difference(P<0.05).The epicardial electrogrophic ST-segment during myocardial ischemia were markedly increased.The myocardial infarct size of the left ventrical in ischemia-reperfusion group and ischemic preconditioning group were 32.2% and 21.6% respectively, its had significant difference(P<0.01).Conclusion Ischemic preconditioning could decrease myocardial oxygen consumption and reduce injury of myocardium and it provides the cardioprotection during ischemia-reperfusion.
出处
《新乡医学院学报》
CAS
1998年第2期105-107,共3页
Journal of Xinxiang Medical University
关键词
缺血/再灌注
预缺血
心肌梗塞
氨基甲酸乙酯
ischemia-reperfusion
ischemic preconditioning
myocardial infarct size
rabbit
urethane
