摘要
目的探讨新型化合物Y-IP5对吗啡诱导小鼠行为敏化和条件性位置偏爱(conditioned place preference,CPP)的影响。方法测定小鼠的自发活动,观察Y-IP5对小鼠自发活动及急性给予吗啡所诱导小鼠高活动性的影响;慢性吗啡处理小鼠,建立小鼠吗啡行为敏化和CPP模型,观察Y-IP5对行为敏化形成、转化、表达及CPP形成的影响。结果单次或多次给予Y-IP5都不影响小鼠的自发活动,但能抑制急性给予吗啡所致的小鼠高活动性(P<0.05);Y-IP5本身不诱导小鼠形成行为敏化和CPP,但能抑制吗啡诱导小鼠形成行为敏化和CPP(P<0.05),但Y-IP5对吗啡诱导小鼠行为敏化的转化和表达无抑制作用。结论Y-IP5对阿片类药物的精神依赖可能具有干预作用。
Aim To investigate the effects of Y-IP5 on morphine-induced behavioral sensitization and CPP in mice.Methods Locomotor activity was detected after Y-IP5 administration or co-administration of Y-IP5 with morphine in mice.Mice were treated with morphine to induce behavioral sensitization.Then the effects of Y-IP5 on the development,transfer and expression of morphine-induced behavioral sensitization were investigated.Mice were treated with morphine to induce CPP.Then the effect of Y-IP5 on the acquisition of morphine-induced CPP was studied.Results Y-IP5 itself didn＇t influence locomotor activity of mice.Co-administration of Y-IP5 with morphine inhibited morphine-induced hyperactivity （P〈0.05） and the development of morphine-induced behavioral sensitization in mice （P〈0.05）,however,did not influence the transfer and expression of morphine-induced behavioral sensitization.Co-administration of Y-IP5 with morphine also inhibited the acquisition of morphine-induced CPP （P〈0.05）.Conclusion Y-IP5 may inhibit the psychological dependence induced by morphine.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2009年第12期1578-1583,共6页
Chinese Pharmacological Bulletin
基金
国家高科技研究发展计划(863计划)资助项目(No2003CB515400)
国家自然科学基金资助项目(No30472017)
