摘要
目的:探讨早产儿尿S100B水平的变化及其与早产儿早期脑损伤的关系。方法:将新生儿分别于生后24h及120h留尿测定S100B水平,其中84例住院早产儿和26例足月儿(对照组),观察患儿临床表现并进行头颅B超检查,对各胎龄组早产儿尿S100B水平及脑损伤进行评估。结果:各无脑损伤胎龄组生后24h及120h尿S100B水平差异具有统计学意义,随胎龄增加呈下降趋势。早产儿脑室周围脑室内出血(PIVH)27例,其24h及120h尿S100B水平均高于无脑损伤组(P<0.05);红细胞增多症10例,头颅B超未见异常,但尿S100B水平高于无脑损伤组;脑室周围白质软化(PVL)3例,尿S100B升高。早产儿痊愈54例,好转27例,恶化及死亡3例,病情恶化及死亡者尿S100B值高于痊愈和好转患儿。结论:测定早产儿尿S100B水平可早期发现PIVH、PVL及其高度可疑病例,应进一步检查并予以保护性治疗并加强随访。
Objective： To investigate the changes of urinary S100B protein concentrations and their relationship with brain damage in preterm infants there of . Methods： The urinary S100B protein of 84 preterm infants and 26 full term infants, which were used as control, were measured at 24 h and 120 h after birth. At the same time, routine clinical observations, neurologic patterns and ultrasound screens were recorded. The value of urinary S100B protein and brain damage were evaluated in preterm infants with different gestational age. Results： The differences of urinary S100B protein were statistical significance between the different gestations. The levels of urinary S100B protein were higher in preterm infants, whose gestations were lower than 32 W, than those of other groups. The levels of S100B protein were significantly higher in samples of 27 peri-intraventricular hemorrhage （PIVH） and 3 peri-ventricular leukomalacia （PVL） than those in samples without brain damage （ P 0.05）. The S100B levels were significantly higher in urine of 10 preterm infants with polycethemia than those in infants without brain damages. In addition, the S100B levels were different in urine of preterm infants with different prognosis. The S100B levels were significantly higher in urine of infants who died or deteriorated than those of others （P 0.05）. Conclusion： There is an evident trend of decrease in urinary S100B protein concentration with increasing gestational age. It will be helpful to identify preterm infants with PIVH,PVL and high risk of brain damages by measurement of S100B protein in urine early after birth, which indicates further inspection, provides protective treatment and enhances follow up.
出处
《天津医药》
CAS
北大核心
2009年第12期1026-1028,共3页
Tianjin Medical Journal
基金
天津医科大学第二医院科研基金资助项目(项目编号:Y200605)
