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胃肠道间质瘤多层螺旋CT特点与恶性分级相关性研究 被引量:8

Study on the MSCT features of GIST and the correlation study of malignancy grade
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摘要 目的:探讨胃肠道间质瘤(GIST)的多层螺旋CT征象与恶性分级的相关性。方法:回顾性分析64例胃肠道间质瘤的资料,所有病例均行多层螺旋CT平扫及增强扫描,并经病理免疫组织化学检查证实。结果:间质瘤以胃部多见,占62.50%(40/64),其次为小肠,占18.75%(12/64)。GIST多表现为类圆形实性,边界清楚(47/64),以外生性生长为主(32/64)。密度多不均匀,坏死(47/64)、溃疡(31/64)常见,以不均匀强化、延迟强化为主。肝脏和腹腔为主要转移部位,转移灶坏死常见,也呈延迟强化。11例GIST伴发其他肿瘤。GIST的部位、坏死与溃疡的存在、强化方式及转移灶的有无与恶性分级呈正相关(P<0.05)。结论:胃肠道间质瘤的螺旋CT表现具有一定特征,并且不均匀强化方式,CT图像上坏死与溃疡的检出、转移灶的出现以及发生部位有助于对恶性间质瘤的判定。 Objective: To discuss the sign of gastrointestinal stromal tumors(GISTs)in spiral CT and to a- nalysis its malignancy grade. Methods: Sixty-four cases of GISTs were analyzed retrospectively, all were checked by multi- slice spiral CT plain and enhancement scanning, and had immunity histochemistry con- firmation. Results: The tumors were more in the stomach (40/64), the stomach body (n = 16) and the fundus (n = 11), and then in intestine (12/64). Most GIST were heterogeneous solid mass with clear boundary (47/64), exophytic growth (32/64), and always had necrosis (47/64) and ulcer (31/64), which had nonuniform strengthen, especially in delayed enhancement. Liver (11/13) and peritoneal (5/13) were the more likely metastatic sites. 11 cases were accompanied with other tumors. GIST size, with necrosis and ulcer, non-uniform strengthen and had metastatic location had positive relationship with malignancyo(P 〈0.05). Conclusion: GIST has some characteristic findings in Spiral CT. Some CT features maybe helpful in analysis of GIST malignancy grade.
出处 《新疆医科大学学报》 CAS 2009年第12期1728-1731,共4页 Journal of Xinjiang Medical University
关键词 胃肠道间质瘤 X线计算机 恶性分级 gastrointestinal stromal tumors X-ray computed malignancy grade
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  • 1娄越亮,陈华,张燮良,战忠利.96例胃肠道间质瘤临床诊治分析[J].中华肿瘤杂志,2004,26(7):437-439. 被引量:25
  • 2白月奎,邵永孚,石素胜,高燕宁,孙耘田,程书钧,刘秀云.胃肠道间质瘤预后多因素分析[J].中华肿瘤杂志,2005,27(10):598-601. 被引量:22
  • 3贺慧颖,方伟岗,钟镐镐,李燕,郑杰,杜娟,衡万杰,吴秉铨.165例胃肠道间质瘤中c-kit和PDGFRA基因突变的检测和临床诊断意义[J].中华病理学杂志,2006,35(5):262-266. 被引量:73
  • 4郑松,陈丽荣,王海军,罗月球,朱永良,程水珍,周燕.PDGFR-α在胃肠道间质瘤中的表达及其临床意义[J].浙江大学学报(医学版),2007,36(3):280-284. 被引量:6
  • 5Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science, 1998, 279 : 577-580. 被引量:1
  • 6Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science, 2003, 299:708 710. 被引量:1
  • 7Fletcher CD, Berman J J, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: m consensus approach. Hum Pathol, 2002, 33: 459-465. 被引量:1
  • 8Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors: the incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era (a population-based study in western sweden). Cancer, 2005, 103: 821-829. 被引量:1
  • 9Miettinen M, Lasota L. Gastrointestinal stromal tumors - definition, clinical, histological, immunohistochemical and molecular genetic feature and differential diagnosis. Virchows Arch, 2001,438: 1-12. 被引量:1
  • 10Kontogianni K, Demonakou M, Kavantzas N, et al.Prognostic predictors of gastrointestinal stromal tumors: a multi-institutional analysis of 102 patients with definition of a prognostic index. Eur J Surg Oncol, 2003, 29: 548-556. 被引量:1

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