期刊文献+

联苯取代1,3,4-噁二唑-2-硫酮的合成与表征

Synthesis and Characterization of 1,3,4-Oxadiazole-2-thione Derivatives
下载PDF
导出
摘要 以不同的芳香酸为原料,经酯化、氨解、环化反应合成了一系列1,3,4-噁二唑(4a^4e)。4中的N-H键与2-氰基-4'-溴甲基联苯经缩合反应合成了具有多种潜在生物活性尚未见文献报道的标题化合物5a^5e。5的结构经1HNMR,IR和MS表征确认。 A series of 1,3,4-oxadiazole-2-thione (4a-4e) derivatives were synthesized from aromatic acids via esterification, ammonilysis and cyclization. Reaction of 4 with 2-cyano-4'-bromomethyl biphenyl gave novel compounds 5a-5e with potent bioactivities, which were never reported in the literatures. 5 were confirmed with 1H NMR, IR and MS.
出处 《精细化工中间体》 CAS 2009年第6期55-56,68,共3页 Fine Chemical Intermediates
关键词 氨解 环化 1 3 4-噁二唑 2-氰基-4’-溴甲基联苯 ammonilysis cyclization 1,3,4-oxadiazole-2-thione 2-cyano-4'-bromomethyl biphenyl
  • 引文网络
  • 相关文献

参考文献4

  • 1Hwang S W, Chen Y. Photoluminescent and electrochemical propertiesof novel poly ( aryl ether) s with isolated hole-transporting carbazole and electron-transporting 1,3,4-oxadiazole fluorophores [J ]. Macromolecules, 2002, 35 (14) : 543 825 443. 被引量:1
  • 2Zou X J, Lai L H, Jin G Y. et al. Synthesis, fungicidal activity, and 3D-QSAR of pyridazinone-substituted 1,3,4-oxadiazolesand 1,3,4-thiadiazoles [J]. J Agric Food Chem, 2002 , 50(13): 3 757-3 760. 被引量:1
  • 3Ponticello G S, Engelhardt E L, Baldwin J J. Synthesis of 2-and 6-chloro-3-(5-methyl-1,3,4-oxadiazol-2-yl)pyridines[J]. J Heterocyclic Chem , 1980 , 17: 425-427. 被引量:1
  • 4Kurup A , Garg R, Carini D J, et al. Comparative QSAR: An giotensin Ⅱ antagonists[J] . Chem Rev, 2001, 101 (9) : 2 727- 2 750. 被引量:1
;
使用帮助 返回顶部